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STAP˦

ƤSTAP˦ӥͥܤ򳰤ǿ̲塹ȹԤƤ롪ϡСؤ°±õд

STAP˦ӥͥפĤ˲ƤǻϤޤä ٤Ƭܤϵޥ͡Ρ٥ޤƨܤˡ

2016.06.01

2016-06-05_004747

STAP˦ʸű󤵤졢Ҥ󤬷ǽ른ǥ˥塼ˤʤΤǶܡϵ΢¦ǤSTAP˦ӥͥܤ򳰤ǿ̲塹ȹԤƤ褦ޤŪʾ󤷤äƤʤʤȤҤȤĤˤĤʤԲĻ׵Ĥʾ󤬤դĤ롣

ϡСؤ°±õд

ҤȤĤꥫΥϡСؤ°±STAP˦˴ؤõдϤǷ³ƤȤʸȯɽǥϡСɤƹ񡢲ʥȥꥢܤSTAP˦õдꤷΤԻ׵ĤʤȤظ꤬ʸ겼⡢ʤϡСɤõμֿ䤽ϰϤ䶯10ɥʾѤ򤫤³ƤȤΤ

дꤷõ겼ˡդ˿׵˵ۤΥޥ͡ƤȤΤϡ줬衢ʬǥͤˤʤȤ餫ξĤǤ뤫ȹͤƴְ㤤ʤºݡϡСɤιư򸫤ȡΥեǤ롣

Ȥоһμ¸ץȥǤϥ󥸲̽٤λ٤μ夤˺˦򿻤ȤǺ˦νԤȤ礬Ǻƻ֤Ϥꤨ̵פȤФƤ롣ϡСɤõдꤷƤϰϤϼ¤Ϥ⹭

ϡСɤǤϤ깭ϰϤõоݤȤơ֤ޤޤˡǺ˦˥ȥ쥹Ϳ뤳Ȥǵ˦νΡפõϰϤȤƤΤ

2016-06-05_004828

ϥǥ٥륯ؤǡֽSTAPפǧ

ǯ3ˤ⤦ҤȤĤξӹǤɥĤΥϥǥ٥륯ؤθ楰롼פȰۤʤﲼǼ¸ԤäȤSTAP˦ǤȤΤʸȥϡModified STAP conditions facilitate bivalent fate decision between pluripotency and apoptosis in Jurkat T-lymphocytes٤Ǥ롣

θ漼STAP˦Ǥ뤫ɤ򸡾ڤǡϥǥ٥륯ؤǤϡѤ˦μȻǻ٤ѤơޤޤʾﲼǼ¸Ԥä

JurkatT˦Ȥ˦ʤǤޤ褦ʡʾʸ˹⤤ǻ٤αդ˿ˡͭդʿκ˦ȥ쥹Ӥǽ˦ѲӤȤΤ

ϥǥ٥륯ؤǤϤθݤSTAP̾դĤޤ긷̩˾ˡǤϤʤﲼǤSTAPݤǧ줿ΤǤ롣

ϥǥ٥륯ؤˤСΤ褦ʶΥȥ쥹򤫤ﲼǤ¿κ˦Ǥޤǡκ˦¿ǽӤȤĤޤδŪʾﲼǰκ˦ǽ˦ȤʤѲ뤲櫓

ƱؤǤϡθݤֶ̣並ΥơޤǤꡢ˦λ¿Ͳα̿ʬƤΤ򺣸带椷ƤפȤƤ롣

ơäϡСɤõ᤹ȡΤ褦ʸ̤ɤǽФƤ뤳ȤꤷơϡСɤϡ֤õȤƤϤοϰϤǤפȤĥƤΤȻפ롣

ºݡϡСɤؤԤäĴФơƱʬΥΡȤǡФƤʤ̩΢٤STAP˦ӥͥνѤƤ뤫

õǤФ줫20ǯ֡STAP˦ѤŤʼϥϡСɤ᤹롣STAPݤ򵯤ץȥȯԤˤϥΡ٥ޤͿޤǺǽ󾧤ǤϤʤǽˡȯԤФƤפȱϥꥫȲδ֤ǡʬˤʤ̤ˤʤꤽ

ʸᲦСХ륳󥵥ƥ󥰥ե˶̳ӥͥå㡼

ȸ TOCANA




STAP˦ư۾ҡֲԤES˦櫤˥ϥ줿

®۾ҤܤǡֲԤES˦ƻϥϥ줿

2016ǯ127

and_553169

STAP˦¤Ǥ֤ɤ¸ߤ뤳ȤǤʤޤ࿦ҤܤǤ뤳ȤʬäamazonͽˤʤäƤΤϡ֤פȤܡɮԤϡ־ҡפȤʤäƤ롣

ҤϹ̼ҤȯǡŻҽҤȤɤKindleܤȤʤäƤ롣Ĺϻܤ˴258ڡ̤ϾʤᡣˤʤƤϤȤȡԤ֤ȤSTAP˦ưˤĤƾλ֤줿ŤʰȤʤäƤ롣ܤϸͽȤϸʤҲʸ򸫤ȡ櫤ˤϤ줿פȤǽ񤫤Ƥ褦

ӣԣưοꡢ̿ʳس롢ȲФ˾Ƥʹ֤̤֤ä׷μ국
Ԥؤ̴ܥȥΥݥץڡե˦ ޥ롡륹פȤΥƤ桡ʸԴ֤ξ͡Ϥ뤫Ķȿϥϳ줿οʤäΤ10 ǥࡡ11ʸű12Ȥޤ줿ţӺ˦ȡ꡼13Ȳetc.



ܤ٤12ϤΡֻȤޤ줿ţӺ˦ȡ꡼פԤδ֤ǤϤθĴǾҤSTAP˦̾դΤES˦Ǥ뤳Ȥ餫ˤʤä12ϤϤλ¤ƧޤơïES˦Τȿͤ仡ΤǤ

ʤnetgeekǤϰƱ漼AҤ㤤ES˦ƤޤܤΤݤۤäƤơθϤۤФߤʤ鴪㤤޾ФäƤפȤȡ꡼ŸƤϤʤְ㤤ǤϤʤΩƤäΤǤϤʤ

͡Ҥ٤줿AҤ΢ȡ꡼STAP˦ϻΥߥޤ줿ۤʤǤ

ҤϺǸޤSTAP˦Ϥȸ³ƤνҤǤES˦äȤȤǧƤ롣

stap_obokata4

ƻ륫֤ǤκǸκƸ¸Ԥ˽äƤ⾮Ҥϡ֤ǤSTAP˦Ϥ롣̤줿©ҤΤ褦¸ߤʤΤǤĤɬĤƤߤפȼĥƤSTAP˦μ¸˲٤Ȥڸű󤷤ʤäˤ⤫餺ˤơ֥ϥ줿פȸФΤϲ꤬뤫ʤΤ

ͤϻ֤ФĤ͡ʴ졢ҴŪ˼ʬߤ뤳ȤǤ褦ˤʤȤ

obokataharuko_ura

ǤˤäƾϤޤϤ֤Ǥ򤫤ȤպᤷζȤΤϲäΤܤӤˤϡֿ¤Ĥ᤿ΤïפȤʸ礭ʸǺܤƤ롣

ȸ netgeek


국ǡӣԣưֿ¤񤳤ȷ᤿

2016ǯ128 05:30

2016-01-28_155538

ӣԣк˦ʸԤäظθһʣˤμ국̼ҤǤ롣᤬࿦塢ޤȤޤäĥ򤹤ΤϽơ֤פꤷƱǡϢưˤĤơֿ¤񤳤ȷ᤿פȼɮưˤä¸ߤꤵ줿ӣԣк˦˼ºߤ뤫ɤˤĤƤϿƤʤ

餬Dz񸫤֣ӣԣк˦פȯɽΤǯ֥ꥱפȤưοͤˤʤä礦ɣǯܤ˹碌Ĥۤˤä

񤭤Ǥϼɮư֤Τޤ޸Ĥߡ֤˺ƤΤԤĤȤϡʤҤ礦ƨȻפ¤񤳤ȷޤפ̼ҤˤСơؼ국ơƱҹ󼼤ϡԤθɽ뤳Ȥϡӣԣк˦ᤰ뺮θξǰյȹͤƤޤפȤ

ôԤˤС᡼á̤Ǥ碌Ťͤ󣴥ƺǯ˽񤭾夲̳ͤ뻰ڽ۸ΤϡܿͤĴǡä¤񤤤ܤǤפȥȤ

국ϣӣԣк˦ˤĤơٶǤäȤ򡢿ȿʤѤƤޤפȼպᡣ᤬Ԥ֤ϤޤꡢϢưڡϹǤĤŤäƤ롣

ϡֻȤޤ줿ţӺ˦ȡ꡼פϡǯˡֻȤ˻ΩƤưäȻŦԤǸμ㻳ɧ綵䡢̿ʳظ楻󥿡꼡Dz񸫤򳫤᤬ţӺ˦Ȥäƣӣԣк˦¤ʤͤĤˤ褦˲ȼĥƤ롣

ưαˤäǯ˼ʤκ˧ˤĤƤϡϡֶȲСפǡֺˤʤää϶ȲФ˾Ƥ³̵ʪˤʤäפȥå礭ɽڼ¸ˤϡνŤޤȤ

֣ӣԣк˦ϤޤפǸƱǯβ񸫤΢¦򡣲񸫣Ĵɤ񸫤ơ±ƱȱڤäƤäƤ桢ƻդ齵ϤƤ줿Ūˤ夷ƤϼȤμ̿ܤäɽ򸫤Ƶ䤷Ȥ

ƱǤϣӣԣк˦ˤΤɤȤ˿ˤϿƤʤߤꤸ줿Ĵǣӣԣк˦¸ߤꤵ줿ȿǤ꤬dzǽ⤢롣

ǵǰ񸫳̼Ҥˤȡ֤פϽǣǣߡ̡ˡǤ˴ؤƾ᤬Բ񸫤򳫤ͽϤʤȤŪԤؤΰǤ󣱣Ȥߤ졢Ƿ׻硢μ긵Τ󣷣ߤˤʤ롣

ȸ ݥ˥




ҤSTAP˦¸ߤ롪ƸԤʪŪʥȥ쥹Ǻ˦STAPݡ׳ǧϥǥޤä

STAP˦¸ߤƤȤʸͥ㡼˷Ǻܡעͼ¤ϥǥޤǤڤäư

2015.12.12 21:38

2d03f5a9-s

ҤȯϿ¤äͥ㡼˥ޥκ˦¿ǽġSTAPݡפꥫθԤˤȯɽޤ


2015ǯ1210

Ҥȯֳȥ쥹ˤκ˦¿ǽġסSTAPݡפ¸ߤ𤹤ʸʳػ֥ͥ㡼פλǥ饤ΡNature.com SCIENTIFIC REPORTSפˣǯդǷǺܤ줿

Characterization of an Injury Induced Population of Muscle-Derived Stem Cell-Like Cells »ͶƳˤͳδ˦ͺ˦iMuSCs

Characterization of an Injury Induced Population of Muscle-Derived Stem Cell-Like Cells

ʸμưͭ

ڲΥȥ쥹ˤκ˦¿ǽSTAPݤƱ̡

Ǥޥιʶڤ鴴˦ˤʤ뿷κ˦ĤȯȤ롣 ʪŪȥ쥹κ˦졢¿ǽġפȤSTAPݤƱƤ롣ޥ¸Ǥ⤳κ˦¿ǽѲ¿ǽ˦Ǿ١¡ˤGFPǧ줿Ȥλ

ں˧Τζäϴ˦ؼԤȤä

κ˦ʪŪװ̤ʬξ֤ꡢ¿ǽĺ˦Ѳ롲Ρֻαդ˿륹ȥ쥹ˤ˦̤ʬξ֤ꡢ͡ʿΤȿʬǤ¿ǽ˦ˤʤ׻STAPݤ̾դ̤Ʊȸ롣

ɷˤꡢκ˦򴴺˦˽ȤSTAP¸ˤĤƸκ˧Ρʵǯˤϥͥ㡼εԥǥӥåȻˤä餷̤Ǥ伫ȡΥȥ쥹˦ˤΤ褦ʸ̤⤿餹ȤϻפäƤߤޤǤפζääΡ٥޵θԤǤ⡢פʤ̤Τκ˦֤ȯƤΤ

ھҤȯϿ¤ä줿

ҤϺ˦桢˦˥ȥ쥹򤫤ʬ¿ǽĤ褦ˤʤ륢ǥ⤫ȤΥͥ㡼ǾΥǥܶڤϴְäƤʤä줿Ϻ˦˥ȥ쥹򤫤¸դǤϤʤ˦˷򳫤ˡʪŪʤɤ¿ǽޡȯ褦ˤʤä𤷤Ƥ롣

STAP˦ƱʪǤϤʤSTAPݤȤ˦νϾ줿

ʪŪǺ˦¿ǽĤȤ븽ݤ𤵤줿ˤꡢ˦ץߥ󥰤롢Ȥäֺ˦Ϥäʬ̤ʬξ̵֤˦ʬʤǹԤסκ˦̤ʬ˦ˤʤꡢ˦֤Ȥƿȿ褦ˤʤʤƻϤʤפȤSTAPɤϤμ¸̤ɤΤ褦ªΤ

ʸ˰Ѥ줿ʸ

ϡСαػ˽񤫤졢֥ƥå塦󥸥˥󥰻פ˷Ǻܤ줿The Potential of Ston Cells in Adult Tissues Representative of the Three Gern Layers κ˦¿ǽĤ褦ˤʤ븦椬¸ʳǤ򼨤˰ѤƤ롣ιͿˡ¿ǽ˦ˤĤƽ񤤤ʸήθãλͤˤʤäƤϤʸ򸵤ʸ񤤤ְäƤܤؤФˡˤذ̤μͿפȽꤵ졢ذ̤å줿

ոۤԤޤ̿ġޤߡ <mjp@mbr.nifty.com>

Ϣ֥̿STAP˦ʸĴѰ𡢲װؤκŪ

81bbfe5b

ڥͥ㡼ʸܸ

Abstract

桹ϺǶᡢޥʶڤδ˦οʽĤȯޤνͶƳζͳ贴˦ͺ˦iMuSCsˤʬŪʬڸ˦ƥץप¿ǽΤ褦ʾ֤ɽƤޤΤ褦ʿӶڸʬʤɤʣηʬǽϤޤiMuSCsŸ˦;Ϥޤin vivoǤζζϤǽϤ¾ڤͥ줿ܹ̤ɽޤ

IMuSCsˤϡĤ¿ǽӶڸ˦ޡȯޤεڤӴǽϤͭ3ĤΤ٤Ƥդʬ뤳ȤǤޤޤ˦Υޥ󥸥ϡiMuSCs˹׸ãλǤʤäȤ򼨤ޤ桹η̤ϡiMuSCsʶڤĶˤä줿¿ǽʬŪ˺ƥץव줿֤Ǥ뤳Ȥ򼨤Ƥޤ

IntroducionƳ

»ȿϡȿΤӴ˦γӶɽꤪȤο˱˦ο¿ޤʣʪŪץǤӮưʪιʶڤκˤϡݤδȶں˦δ֤˰֤ñ˺˦νĤǤ˦ȶ˦MuSCsˡʤɤξcells1,2γ˰¸Ƥޤ

MuSCsϡ˦εǽŪԶѰʽĤǤꡢ®١ޡȯץե롢ʺǽϡʬcapacities2,3äƤޤ桹ϰMuSCsiMuSCsξĤ¸ߤ뤳Ȥȯ桹laboratory4dzΩCre-loxPƥѤ»ޥιʶڤñΥ뤳ȤǤޤ

桹iMuSCsϡCD34ȯSca1ʺ˦-1ˡPAX7ʥڥܥåѥ7ˤǤʤvivo5˶ڸʬӶκǽϤ󼨤ǤʤȤƤޤ

ˡ桹iMuSCsϡ˦εư򴴼¾ڤΤ褦muscle4ˤCD31 +ͺ˦ʤɤڸʬ뤳ȤǽǤ뤳Ȥ¾ڤޤǤϡˡη֡ޡȯץե롢¿ǽϤĻǽϤʬǽϤ˾ơiMuSCsͭĴ٤ޤ

Results

桹γΩ줿˦ʬΥˡʿ1aˤŬѤ뤳ȤˤiMuSCsޥTA˶ڤñΥޤ塢˦ñΥ塢iMuSCsζں˦Ĥ0.1ˤܻ˸ޤ˦ϡоȤΩ줿ʪ¸ߤƤʤ̵ζʿ1bˡɾϡɽiMuSCsϡľ5-7ߥǤäŪ礭ʳˤȺ˦ζबޤޤƤ뤳Ȥ餫ˤʤޤ

γˤMSX1MSHۥᥪܥå1˼­S1aȡˤȥإ33342Ӽޤ줿BrdUʥ֥ǥꥸˤȤʤޤPAX7ȤSca1ʿ1cˤȯ뾯κ˦ǤäΤ˦ñΥޤiMuSCsνο͸MSX1CXCR4CXC⥫Υ4ˤγ礬⤤ޤޤƤޤ

TAΰȯʬϤϡMSX1ʤޤPOU5F1ȸƤФˤOct4Sox2̵Ťڡʿ1d­ޤӤƥåץ쥮졼ȡSRYܥå2ˤNanogȯޤS1bˡñΥiMuSCs϶ڸ˦ϢޡʤSca1PAX7CD34ӥ¿ǽޡҡʤOct4Sox2ΤNanogȯʿ1Eڤ­ޡS1cˡ

iMuSCsϡ13֤ʿѤκ˦Ĥܲû֤ͭĹin vitroޤ˦ŪϤϡiMuSCsʽ˷äƤȤ餫ˤޤΰ۾ϡ5­S1DˤΤΥȥ꥽ߡǡη̡Ĺܡʷ33ˤδ֤˸ޤ

ޤiMuSCsޥ졼ͭƤȤȯޤץưåΥǡϡiMuSCsоȥޥڲ˦C2C12٤Ĺ⤤®٤ȵΥܹԤƤ뤳Ȥǧȥ뤫ʬΥMuSCsϡʿ1F˶̵ޤiMuSCsmRNA٥ʿ1GˤǦ¥ƥ˥󤪤ӤĤΥɥإ٥ȯޤ

γ¿ǽʬåiMuSCsMyHC +ʥߥźMuSCsC2C12ڲ˦ʿ2aˤƱͤͻ祤ǥåĶʬǶڴɤͻ礹뤳ȤǤȤ򼨤ޤ iMuSCsBMP2ȹι­S2ˤʬ뤳ȤǽǤ

iMuSCsñĸŪˡ콵֤Τ˿д˦ϡˡ򻲾ȡˤǰܥ˥塼եη𤷤ƿͶƳ뤳ȤǤʿ2bˡ켡ڲ˦MuSCsϤι¤򼨤ޤǤ iMuSCsˤäͶȯ˥塼եϡɽ򼨤ͥCNPNefmʥ˥塼եȡˡʿ2bˤɽޤ

3ָ塢ʬϤ˥ߥ˥/ݥꥪ˥󥳡ƥ󥰤ñܤǥåƥ˥塼եϡĤμפʿзʥ˥塼󡢥ȥȡӥꥴǥɥȡˤʬ뤳ȤǤMtap2ɽ¥塼֥IIINefm ͥ󤪤Olig1 / 2ʥꥴǥɥž̰1/2ˡʿ2BC

iMuSCsεĴ٤뤿ˡ桹ϡin vivoܿǹԤޤ iMuSCsMuSCsƱΤ6 6-8ͺmdx / SCIDޥʥ㥯󸦵ꡢƹˤTAڤͤޤ󻰽֤κ˦ܿ塢桹ϥۥȤTAΥ桼ȥեȥȥեʿ2dˤȯ򸡽ФiMuSCsMuSCsʿ2dˤӤơ礭궯Ǥʥȥե+ܿҤƤ뤳Ȥѻޤ

桹ϤޤiMuSCsΰҵڤӥѥȯץե餫ˤ뤿ˡŪꥢ륿ݥ顼ϢȿqPCRˤȱȿʬϤԤ˦ESCˤӶڸ˦C2C12ڤMuSCsˤˤӤޤ iMuSCsESCΤƱͤˡB3aڤ­ޤS3aˤOct4SSEA1ʳðŪ1ˡSox2ΡCXCR4MSX1PAX7ȤSca1ȯ㤤ȯ٥ǡ

QPCRʬϤiMuSCsESG1ڤDAX1ʿ3Bˤơ¿ǽޡҤʬȯ뤳Ȥ餫ˤޤESCϰۤʤꡢiMuSCs϶ڸޡҤọ̇Ȥˡϸ˦Ϣޡΰ㤨Blimp1ȥե饸ꥹΤ褦CD45ޤCD90ʿ3cˤȤơ¾η˴ϢҤȯޤǤ

ޤiMuSCsϡ륫ۥեʿ3aˤФǤη̤ϡ餬ڸESCΤ٤ơڸҤ㤨Сȯݻ뤿ᡢiMuSCsϡ˻ƤޤESCΤƱǤϤʤȤ򼨤ưפin vitroǶڸʬ褦ͶƳ졢ǡˡ

iMuSCs¿ǽΤˤ뤿ˡ桹iMuSCs㡼ΡEBˡʿ3deˤ뤳ȤǤ뤳Ȥ򼨤in vitroǤassays6,7ʬԤޤͷܤ7塢EB礷ȯŪʬ򳫻ϤդռͶƳΤˤ2ܤ塢°EBϡФΤ褦ʹ¤¿˶ڴɤ̤ʿ3F Gˡ桹Ϥˡin vivoǴˤäiMuSCs¿ǽƤޤ 7֤SCID١ޥʥ㥯󸦵ꡢƹˤ˰ܿȡiMuSCsϡ90N = 7ˤϡ3Ĥդɽȿޤʿ4a˴ޤȿŪiMuSCsϡСӻȿӾʬ뤳Ȥ餫ˤޤ

ϡܿ줿˦ľܷ줿ȤǧˤϡiMuSCsϡͤ˦-galǻɸ桹LacZʿޤȤΤ٤Ƥ3ĤͶƳΤϡ-gal+˦ޤǤФ4b ˡ

iMuSCsϥޥ뤳ȤǤ뤫ɤɾ뤿ˡ˦åԤäʿ4cˡ桹ϡɸŪprocedures8ʲΥޥ󥸥ˤäƤBALB / cʥ㥯󸦵ꡢƹ˦̤ʬΦ-gal +ñ˦ȤƤGFP-ͽɸiMuSCsܤޤ

桹ϡ6Ŭڤ˳ȯ졢GFP + iMuSCsδͿ򼨤E148ޤ -galGFPȯ˦ι٤ι׸ϡE14Υʿ4cd­S4aǤϡˤǸ뤳ȤǤޤ ȿŪʬϤϡiMuSCsϤ٤Ƥ3Ĥաʿ4Eڤ­S4bȡˤ˴ͿƤ뤳Ȥǧޤ iMuSCs˦ͳ¹ޤ졢˳ȯޤμ¸3󷫤֤塢䤿­ɽS1ˤäޤ줿23ɤλҡ٤Ƥޤ

ʬȱiMuSCsɽޤǤãȱqPCRʬϤϡޡ㤨С桢¡١¡¡ǾʤɤλƤΤĤȿǤLacZ +GFP + iMuSCs¸ߤ餫ˤ4F­ޥƥåS4cˡ

Discussion

̷⤷̤͡groups9,10,11,12,13,14,15ˤä𤵤ƤΤǡȿˤ¿ǽ˦ͺ˦¸ߤϡǯ֤μȤʤäƤޤϡޤǡΤ褦¿ǽ˦ϡʬκ˦ȿ뤳ȤƤޤ

ܸǤϡ˦κƥץߥ󥰤ʶڤƤȤȯ붯ɷ㤹뤳ȤˤäƳϤ뤳ȤǤ뤳Ȥ餫ˤޤΤ褦ˡ桹ʶڤƥץवiMuSCsñΥ뤳ȤǤޤ

ޤȤȡ桹θϡiMuSCsޤǸ椵줿٤Ƥκ˦Ȥϰۤʤʷ֡礭Ӱȯץեˤͭ˦ΥˡʡҴʽĤǤ뤳Ȥ򼨤Ƥޤ

IMuSCsESCɽŪʤĤħɽʺ˦ζ˰Ϥޤ줿㤨緿ˡ⤤/˦桢ޥ¤˼ڤΤοˡɽ1ˤǤʤĤ¿ǽɽǤʤޡҤϡڸҤι⤤ȯ٥ݻޤ

ޤܸκǤܤ٤ȯiMuSCsϡin vitroin vivoǤ¿ǽΤδΤĤȤȤǤ桹ϡ˦Υޥ󥸥ãiMuSCs뤳ȤǤޤǤiMuSCsϡ¿ǽޡ㤤ȯץե㤨СOct4NanogΡڤSox2ΡˤͭȤESCӤ硢ESG1ڤDAX1ȯ礤ƤȤ¤˵ޤ

iMuSCsˤäƤBlimp1ե饸ꥹӶڸޡҤŪ⤤ȯδѻ˴Ϳ​​뤳ȤäȤ餷Ǥη̤ϡiMuSCs¿ǽԤ餯ζڸȿΥԥͥƥåʵݻƤʤȤ򼨤ƤޤΤ褦DNA顼ޤNanogβȯ˳ʤiMuSCsΤʤϡŪ˴¿ǽã뤿iMuSCsץå夹뤳ȤǤޤ

STAP˦ƻץƥκǿ

ǥޤȤǥޡSTAP˦Ϥޤ
ҤSTAP˦¸ΡȤäȤƻˤĤޤ

ҤȯϿ¤äͥ㡼˥ޥκ˦¿ǽġSTAPݡפꥫθԤˤȯɽޤ

BPOơSTAPƻפˤĤ
ֿ͸θ¤Ԥ ΤBPO͸ѤNHKڥƻﳲ򿽤Ωơ BPO͸Ѥꤷޤ

ȸ Ҥؤƻɵڤ֤ͭβ







εǤϸήƤޤޤꥫʸSTAP˦ꤹƤǤ͡ե֥å֥ξȽǤƤޤȡȤǤʤǥޤƤޤΤդɬפǤ

Τȯɽ줿ꥫʸΰǤSTAP˦θݤꤹ褦ʸդ⤢ޤϤޤǤθݤǡʸƤǧʪǤϤޤ

ե֥åǤ4000ʾ⥷ƤޤǥޤȵĤθƤӤ򤹤褦ˤޤ礦

εθպᤤޤϺޤǰʾ˾󸻤γǧϤ褦Ȼפޤ

ȸ ¤õ֥


STAP˦Ϥƹ˥ѥ줿 STAPݤȹiMuSCs˦

2015.12.14

2015-12-16_181252

ϥΡ٥޵ȯȤޤǸ졢STAP˦θŸϤ¸ΤΤȤǤ롣֥ꥱϽҡˤפȤƥޥǥ夲줿ҡظ긦32ˤϡʸ¤ǤιäФơ䤹äҲ񤫤鴳Ƥޤä

2015-12-16_181241

ߡ֥ꥫθԤSTAP˦¸ߤǧפȤSNS̤ƳȻȿƤǤ롣κϡʳػإͥ㡼٤αĤ륪饤Żҥ㡼ʥScientific Reportsס1127աˤǡƥذҥ塼ȥ󹻤ԥåĥСذθԤȯɽ

Characterization of an Injury Induced Population of Muscle-Derived Stem Cell-Like Cells»ͶƳζͳ贴˦ͺ˦ˡפȤʸȯͤƤ꾮ȯϿ¤ȼĥƤ֥־Ҥؤƻɵڤ֤ͭβפǤ뤳Ȥ䡢ʸºݤɤSTAP˦˾ƤǤϤʤȤ顢ξǥޤǤưⵯƤ뤬̤ƿϤɤˤΤ

äƤޤȡʸǾ᤬ȯȤSTAP˦¸ߤ줿櫓ǤϤʤΰǡԤϡ֥ޥμ褷κ˦˻ɷͿ»ˤȤES˦iPS˦Τ褦ˤޤޤʺ˦ˤʤ뤳ȤǤ˴˦ˡȻɺ˦ǤפȤȤȯɽiMuSCs˦פ̾ŤƤΤǤ롣

Τˡˡ̤ϾSTAP˦ȤϤޤäۤʤ뤬ʣʹФ뤳Ȥʤ˦ǽ˦ˤ˶ᤤĺ˦߽ФȤܤСθʤȤSTAP˦Ʊɸ򸫿ΤǤȤϴְ㤤ʤ

ĻͺȲʳإ饤ưˤĤƸä

Τ褦ˡSTAP˦ϤʤäȤƤSTAP˦ƱͤΤΤ߽ФȤʳس礭ưˤĤơ󥹥󥿡ƥʡĻͺϥȥʤ˼Τ褦˸ä

ֻϡư1ǯۤɤǡꥫSTAP˦Ȼ˦ΤǤϤʤȰȯƤޤϡޤǤΡܤȥꥫˤʳ٤ˤ򸫤餫ʤΤǤ

ֻ涵iPS˦ȯɽۤƱˡꥫΥ٥㡼ȤƱƤʸȯɽƤޤϤĤޤꡢꥫؤΥǡǤȤȤ̣ޤλ˵ؤȤä֤ϡꥫǺȽ򵯤ˤʤ뤿ᡢꥫǤõˡ衼åѤǧƤ餦褦˿ޤ餦ȤǤ

ּºݡƱ褦ʥϲˤ⸫ޤɽϡޤOSإȥ٤ǤȯԤܤ̵ۤڤߤޤꥫܤ˰Ϥ򤫤ơȥ٤зپʤˤʤإɥ٤ĤƥꥫˤܤؤΥץå㡼ϡ̮³Ƥ롣٤ƤΤʤΤǤ

֤ʤߤˡSTAP˦Τ褦ʴñʼˡǽ˦ǤǽˤĤơʳسǤϤäΤΤȤï⤬ǧƤޤޤ˴δܤǤꡢïǽ˸Ĥ뤫äƤΤǤ ֤ޤ2014ǯ˹ʸؤSTAP˦¸Ȥ⤢ޤ˶餬̤ꡣ⥢ꥫΰϤˤä٤Ƥǽޤ

ֺȯɽϡޤʤFakeǤǽݤޤ󡣤STAP˦뤤STAP˦Ȼ˦ɬꡢޤܤȯХꥫ٤ˤȤ¤ϳΤʤΤǤסĻͺ

Τˡؤλ濭ﶵؽī٤Υ󥿥ӥ塼Ǥϡι¤ֿεʤ襤פȷƤ졢Ἣ餳äƤ롣

ִñ˸ޤȡҥȤiPS˦ϼʬΤۤ˺äƤ䡢ȥꥫΥ٥㡼ȤĥޤƱҤõƤ򸫤顢礬˽дꤷƤƤȤۤȤɰʤ⤦褹ĤǤƤ櫓Ǥ͡סʡؽī١2014ǯ117

ޤȥʤȤ᤿ʳإ㡼ʥꥹȤ⼡Τ褦ʸҤ٤

2015-12-16_181224

־ػʸΰѤޤޤ뺣ʸǤSTAP˦¸ߤȤϸޤ󡣤ES˦iPS˦ǤϤʤ˦ǽ˦ˤ˶ᤤ¸ߡiMuSCs˦٤ĤäȤϳΤǤ

ϡSTAP˦ˤĤơ漼¢ˤˤäES˦κäȷŤƤޤ󼨤¸ǡǽ˦ޤƤǽϤޤȤȤǤ礦ϡ餷鲺䤫ʷ̤ǤϤʤϤǤסʲʳإ㡼ʥꥹȡ

2015-12-16_181212

ʤߤˡ̵ռΥåʹȤ֥Сԡʵպˡ׵ѤǾθդʬϤȡϲ񸫤ǡ֤ȤӥͥαĶŪʡġסֻ䤬סֺ줫Ǥ⤽ˤĤơȯɽƥˡפʤɤȯƤȤȽƤ롣ߡܤǤSTAP˦ᥦ路Τ̾Τ褦ʰƤ롣ʣʼФ뤳Ȥʤǽ˦߽ФȤSTAP˦ƱͤΥ󥻥ץȤǤβʳؼԤʶ򷫤깭Ƥꡢ⤽αˤäȤϴְ㤤ʤ褦Խ

͡Ҥؤƻɵڤ֤ͭβסScientific ReportsסܷкѿʹסХӥͥסۤ

ȸ TOCANA




ֻϺ׻ϡSTAP˦ǤΤϡϸ-椷ƤĥȤGHQ¸³ǧ줿롼פǡޤԻΥǡꥫ¦Ϥ뤳ȤȻȤ줿Ȥ⤬ꡢꥫȥ֥֤ȿǤǡǯ奢ꥫ-STAP˦˶ᤤΤȯɽȤ˲Ȼפȸä

ˡֿĿϺ׻᤬Υץˤʤ˺Ѥޤޤͥ㡼-ǺܤΤꤲͥ㡼STAP˦Ǥٺ򤬤äǥꥫΥΡϼ겼ʤäΤȸޤֵܲˮɧ׻Ҥ٤ΤǤSTAP˦ѤꤷߤФ褤ΤǤ-Ȥεˡܤϥꥫο̱Ϥդ館ʤȸä

ޤ֥٥󥸥ߥ󡦥եեɡ׻᤬ʹ顢祦祦Хΰ-ˤ̿3ܤ˿ӡʹ֤ƱҤäƤ뤬ʹ֤ˤϻѤʤǸƤȡѱѤѤΤ٤ȸȬѵ׻ϡҤõäƤ20ǯˤϸǡ¿20ǯǤϥȤǤ¤줿ǯǤ٤ʤȤ׻ΩĤΤ⤷ʤȸä




񸫤STAP˦õ¤򱣤٤äƤϢΰϤǤʲ񸫤򤷤Τ餫





һᡢSTAP˦ƸǤʹ࿦ءĨʬƤ

һʹ࿦ءĨʬƤ

2014/12/20 00:52

mqdefault (2)

STAP˦Ϥޤס200ʾƤޤפʤɤȡ4β񸫤ǸƤ һᡣ 191Ĥηȯɽ줿

ظϡἫȤSTAP˦ƸǤʤäʤɤȤơڼ¸Ǥڤ뤳Ȥ餫ˤǡ᤬ʹ࿦ȯɽ10Ⱦڼ¸꡼ϡSTAPݤƸ뤳ȤǤޤǤפȽҤ٤

STAP˦θڼ¸̤ˤĤơ񸫤Ԥäظꡣ˾λѤϤʤä 12ڼ¸򽪤򡢥եƥӡ֤Ȥ!פࡣ STAP˦ƸǤפȤ䤤Фơ̵Ωä 4ϡSTAP˦Ϥޤס֤錄ȡSTAP˦ϡ⤦200ʾ塢ƤޤפʤɤäƤ

ޤޤˡǹԤ줿ڼ¸ǡSTAP˦Τ褦ʺ˦βϺǤǽϳǧǤʤäޤʸζԤǤ롢ð̤θڥǤ⡢STAP˦ϳǧǤ2015ǯ3ȤƤ¤Ԥˡڼ¸Ǥڤ줿

¿ο̴ͤƤSTAP˦¸ߡSTAPݤκƸǤʤäȤ˴ؤ칻ؤγϡɤƤΤϡַ餯ʤäȤǧ᤿餤󤸤ʤǤסֱ̾־Ǥ褦ʸ򡢤äꤷƤۤʤȻפޤפä

ϤǤ࿦ꤤФƤơƤ뤬ĨʬƤƤȤ ϡͿ줿ĶǤϡθ³ޤǼȤߡϤڤꡢΤ褦ʷ̤ˤȤɤޤäƤޤäȤˡѺǤƤޤפȥȤƤ롣

ֺθ³ס3򤽤ɽᡣ ڼ¸ϡ24֤Υ˥󥰤ˡ3ԤΩ֤ͤξǹԤ줿񸫽λˡƤꡢޥäڥ꡼ᡢֺ塢뤿ӤˡΤ褦ˡȺͰ򤷤褦ʷǡʳؤι԰٤򸡾ڤȤȤϡʳؤˤäƤϤʤʤȤȻפäƤޤפä

STAPưܤβʳسͿƶˤĤơʳإ㡼ʥꥹȤλ׻ϡSTAP˦ˤäơäѤꤽγޤơɾȤΤƤޤä

ʳؤäƤΤϡøʤȤäƤȤդǧޤäƤޤȡǽŪˤϤäѤꡢܤιDzʳؤ˲ͽɤɤ󾯤ʤʤäƤޤȤȤ⡢櫓Ǥ͡פä

ȸ FNN˥塼




STAP˦ƸǤ12ξ һˤĤ줿ͻҤʤ

2014/12/19 18:46

mqdefault (3)

ظϡSTAP˦θڼ¸ǡ ҸȤSTAP˦ǤʤäȤȯɽ࿦ꤤФϡ¿οͤǤ򤫤פȥȤФ

12եƥӡ֤Ȥ!פΥϡ һλѤȤ館Ȥ˿Ȥߡ٤ơȱûʤäƤϡäȲѤ򤷤ơĤ줿ͻҤϤʤä

ϡ11äơSTAP˦κƸ¸Ͻλθ漼ѻߤ졢˹߳ʤȤΤ餻ܿͤ˼षͻҡ åդΡֺƸϤǤΤ?פȤ䤤ˤϡ̵Ωä ̴ǽ˦Ȥơ硹Ūȯɽ줿STAP˦

줫11ä1219ϲ񸫤ԤܿͤԤäڼ¸η̡STAP˦Ǥʤäȯɽ

θڥबԤƸ¸⡢¤ȤƤ2015ǯ3ԤǤڤ줿 ڰ ͵ϡ־顢21դǡؼ٤Ȥݤδꤤ15Ф줿פȸä

ϡ࿦Ф줿200ʾפΤȤϤʤäΤ

ϡ48ˤ錄äƹԤ줿Ƹ¸η̡ǽҤܰ¤Ȥʤп˸STAP˦Τ褦ʺ˦ʸˤ㤤dzǧ٤STAP˦뤳ȤϤǤʤä

꡼ϡ֡пָФ˦Фޤ٤ȤȤäƸΤʤС200ʾSTAPݤϺƸƤޤ٤ȤΩĤȻפޤפȸä

Բ񸫤ϡ褽2֤˵ڤӡڥΥ꡼ϡ١񸫾򤢤ȤˤƤꡢޥ򰮤äϡ֤Τ褦ˡȺͰ褦ʷǡʳؤι԰٤򸡾ڤȤȤϡʳؤˤäƤϤʤʤȤȻפäƤޤפȸä

Ϻθڼ¸ˤĤơͽۤϤ뤫ĶǤκȤȤʤꡢͿ줿ĶǤϡθ³ޤǼȤߡϤڤꡢΤ褦ʷ̤ˤȤɤޤäƤޤäȤˡѺǤƤޤפȥȤ࿦뾮ФĨʬƤƤ롣

ȸ FNN˥塼





®۾ξʡκ˧󥿡Ĺ˴βǽ

˧ ޤä

2014ǯ08051033ʬ

sBxIebo

ӣԣк˦ʸԤΣͤǡͻԤˤظȯʳ縦楻󥿡κ˧󥿡Ĺ󥿡ηʪǼĤäƤΤĤޤ

±˱Ф츽ߡ̿ȤȤǡٻϡ񤬻ĤƤ뤳Ȥ鼫ޤäȤߤƾܤĴ٤Ƥޤ

ʼ˸ٻˤޤȣͻԤˤظȯʳ縦楻󥿡󤬤ꡢٻĤȤ󥿡ηʪǺ˧󥿡ĹĤäƤΤĤޤ

󥿡ű˱Ф졢ߡ̿ȤȤǤٻϡ񤬻ĤƤ뤳Ȥ顢ޤäȤߤƾܤĴ٤Ƥޤ

˧󥿡Ĺʣˤϡưʪοк˦Фʪθ椬ǡʿǯظΥ롼ץǥ쥯˽Ǥǯظȯʳ縦楻󥿡󥿡ĹĤȤƤޤ

Ȥʤäӣԣк˦ʸϡҸ˥åȥ꡼Ԥä¸򸵤ˡ󥿡ĹɮƳǤޤȤƤơظĴѰϡ󥿡Ĺ԰٤ϤʤäΤΡǡʤɤˤĤƼǧ뤳ȤʤʸƤƤơǤϽȻŦƤޤ

ȸ NHK˥塼


˧󥿡ĹĤ꼫ޤ롡˰

2014ǯ85()1029ʬۿ

AS20140417000452_comm

ظȯʳ縦楻󥿡ʿͻˤκ˧󥿡ĹīĤ꼫ޤäϣӣԣк˦ʸǤԤΰ͡ʼ˸٤ˤȡռνΤǵ֤̿Ƥ롣񤬻ĤƤȤ

ڣӣԣǡۺᡢպΥȡȴ

٤ˤȡΣȣδ֤ˤ٤μꤹˤĤפΤ褦ʤΤǡĤäƤΤĤäȤϥĤ˥åѤäȯ졢󤬤ä

ȸ  ʹ

ظθबɷͿǡ˦ˤʤǽ˦פ뤳Ȥ

ʡǽ˦ȯθŸ˴

2014/01/30 05:50

mqdefault (2)

λɷͿǤ˦ˤʤǽ˦פ뤳Ȥظθबޤ

ȯΤϡҸ˥åȥ꡼30ˤθ楰롼פǡǽ˦ȤơSTAP˦פ̾Ťޤϥޥ¸ǡ˦˳λɷͿ뤳ȤǺκ˦ȤƤεõƤӡ¿ǽפäSTAP˦ФȤޤޤȤδ֤Ǥϡưʪκ˦ϳλɷǽ˦ˤʤʤȤߤƤޤ

˥åȥ꡼Ҥ󡧡֤ޤǼοͤ˸äƤ⡢ؤäȤϴְ㤤٤ȤȿäΤǡФ𤷤褦ߤʡ

iPS˦23֤Τ١STAP˦1٤ǤǤΨŪ˺˦뤳ȤǤȤȤǤؤλ濭ﶵϡֽפʸ̤ܿ͸Ԥˤäȯ줿Ȥؤ˻פ塢ʹ֤κ˦⡢Ʊͤμˡ¿ǽ˦뤳ȤԤƤפȥȤƤޤ

ظ



󲽤ˤSTAPǽ˦¸ȯ

2014/01/30 11:48

mqdefault (1)

ESiPS³3ǽ˦ܿͤˤäȯɽޤ̾STAP˦ס˦򳰤ɷ㤹û֤ǸΨɤǤ󲽤ˤޤǤǽ˦ǤԲǽäפˤѲǤޤ

STAP˦̾դ줿ǽ˦κΤϡظξҤ30ˤ꡼̳븦楰롼פǤ¸Ǥϡޥκ˦˳λɷͿ뤳ȤǺκ˦ȤƤεõƤ¿ǽä˶ᤤ֤᤻뤳ȤƾޤҤƳƺiPS˦û֤ưפ˺Ф󲽤βǽ㤤ȤȤǤ

涵iPS˦򸦵桢İ浮Ƿ綵־׷ŪʤΤǤʤȤϤʤȤ촶ƤȻפ

ޤȤδ֤Ǥϡưʪκ˦ϳλɷǽ˦ˤʤʤȤߤƤޤ

˥åȥ꡼Ҥ󡧡֤ޤǼοͤ˸äƤؤäȤϴְ㤤٤ȤȿäΤǡ뿲ˡԤ餳μ¸Ϥ褦ʤȡ礦ϴĥȻפäƤ顢5ǯФäƤޤäȤǤ

ιäƤ鷺3ǯȤԤ̤ȤäȤʤޤ

ظ


Ǽ¸ϡС硢Կ»

2014.1.31 08:30

˦˻ɷͿ뤳Ȥǡޤޤʼκ˦ѲǤǽϤǽ˦֣ӣԣСʥåס˺˦פȤƥϡСΥबԿ»ΥŤ븦ϤƤ뤳Ȥʬäʹ֤κ˦Ȥä⸦椷ƤȤ

ޥκ˦κ𤷤ձѲʳػʸظȶƱǼɮϡСΥ㡼륺Хƥ͹ŪԿ»ƤޤҤ򵯤ʣΥ뤫ӣԣк˦ܿѤ¸򣲣ǯϤƤȤ

ߤʸȯɽν򤷤Ƥ뤿ܺ٤餫ˤǤʤΤΡֶä٤̤ФƤפä̤äȼˡֺǶˤʤäơʹ֤ˤݲ˦ӣԣк˦Ƥߤޤʬ˺˦餫ˤǤƤʤפȽҤ٤

Ѹ
ӣԣСʥåס˺˦ ΤΤޤޤʺ˦ˤʤǽ˦ΰޥηդ˴ޤޤѵ夤ϱդ˿ܤƺӣԣФϡ֣󡡣䡡桡ʥƥߥ饹ȥꥬɡ󡡥֡ץݥƥ󥷡ˡפάֻɷ浯¿ǽפ롣͹¿ǽ˦ʣУӺ˦ˤñ˺ǤУӺ˦ʤפǤ

ȸ пʹ







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