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ƥեؤȥߥذرθबʹ֤ΥΥ8%Ρ֥ꥢDNAפƤȯɽ

ʹ֤ΥΥ8%Ρ֥ꥢDNAפƤƹʳإǥߡǺܡ Υ륹

2016.10.29

ֲ桹Ϥɤ褿Τ 桹ϲԤ 桹ϤɤعԤΤסե󥹿Ͳȥ䤤򺣰䤤ľ褿⤷ʤʤȡΰˡ֥ꥢDNAפ¸ߤȤسθ̤𤵤ƤȤΤ

2017-02-17_074705

奨ꥢDNAȯ줿

ƳǥȤȡƥեؤȥߥذرθब椫齸줿︳2500ͤDNAĴ̡19Ρ󡽥ҥͳDNAʥꥢDNAˡפͤΥΥˤ¸ߤ뤳ȤȽ322դΡƹʳإǥߡסProceedings of the National Academy of Sciencesˡ٤˷Ǻܤ줿ƤȤ

˶ä٤ȤˡĴ25002︳ԤˤϥꥢDNAδʡȥ쥷ԡɤĤƤ뤳ȤޤȽƤ뤽ΤDNAϲʤΤ

¤ϡꥢDNAΤϡHIVʥҥȱ륹ˡפɽȥ륹ΰȥ륹HERVˤȤȤʬäƤ롣ȥ륹Ȥϡȥ륹餫θǥΥ˼ޤ졢ˤ錄ƤΤʹ֤ΥΥ8ƤȤ⤤Ƥ롣

HIVʹȶ륹Τ褦ʹ뤬פκǾ˦γˤȥ륹ȯƤꡢʹ֤ʲԲķ̤Ƥ

θ̤ϡȥ륹ȿʹ֤δط˿ʻ󶡤ΤˤʤȸΥ륹ؼԥ󡦥եΡʥեءˤϸäƤ롣

֤ɤΤ褦ʷаޤǥȥ륹ȿʹ֤Ȥ˿ʲƤΤפʾ餫ˤʤޤ
ָ˵ä륹ȯŪǤ뤫⤷ޤ

2017-02-17_074824

ޤǤθǤϡȥ륹ϥʤɤµνɼ˥᡼ͿΤȤƴϢդ褦ȤƤˤϽɼοʲ¥ΤǽǯŦƤ롣ƱԤǤ륿եإ꡼ȡꥢॺΤˤȡ֤ޤƤȥ륹ĤäƤʤȤξ㳲ˤʤäƤפᡢֺ夵¿οͤоݤ˥꡼˥󥰤ɬפפȤΤȡ

ؼԤΥե꡼åΤ⺣θ˹ʤǮդ򸫤Ƥ롣

ְҤȯ˱ƶͿ¾ȥ륹Υץ¿ȯƤޤסʥåΡ ֺΥ᥽åɤѤơҤƤȥ륹õƤĤǤסƱ

Τ߷׿ޤȤ⤤٤DNAֿʹ֤餷ʤΡפǹƤȤسθ̡륹ʤɤ̿ϵ峰褷Ȥ֥ѥ󥹥ڥߥפˤʤ館Сʹ֤ϤǤϵ峰̿ΤȤΥϥ֥åɤȤȤͤ桹ϰβԤʤΤġġ

Խ

͡University of Michigan Health SystemסScience DailyסDaily Mailסۤ

ȸ TOCANA


More ancient viruses lurk in our DNA than we thought

One whole endogenous retrovirus genome -- and bits of 17 others -- were spotted in a study of 2,500 human genomes
ANN ARBOR, Mich. — Think your DNA is all human? Think again. And a new discovery suggests its even less human than scientists previously thought.

2017-02-17_075810

Nineteen new pieces of DNA -- left by viruses that first infected our ancestors hundreds of thousands of years ago -- have just been found, lurking between our own genes.

And one stretch of newfound DNA, found in about 50 of the 2,500 people studied, contains an intact, full genetic recipe for an entire virus, say the scientists who published their findings today in the Proceedings of the National Academy of Sciences.

Whether or not it can replicate, or reproduce, it isnt yet known. But other studies of ancient virus DNA have shown it can affect the humans who carry it.

In addition to finding these new stretches, the scientists also confirmed 17 other pieces of virus DNA found in human genomes by other scientists in recent years.

The study looked at the entire span of DNA, or genome, from people from around the world, including a large number from Africa -- where the ancestors of modern humans originated before migrating around the world. The team used sophisticated techniques to compare key areas of each persons genome to the reference human genome.

Working at Tufts University and the University of Michigan Medical School, the researchers made the findings with funding from the National Institutes of Health.

HERV-enly find

2017-02-17_075913

The findings add to what science already knows about human endogenous retroviruses, or HERVs. Thats the name for the ancient infectious viruses that inserted a DNA-based copy of their own RNA genetic material into our ancestors genomes. Theyre part of the same type of virus that includes the modern human immunodeficiency virus, which causes AIDS.

Over generations, the virus-generated DNA kept getting copied and handed down when humans reproduced. Thats how it ended up in our DNA today. In fact, about 8 percent of what we think of as our human DNA actually came from viruses. In some cases, HERV sequences have been adopted by the human body to serve a useful purpose, such as one that helps pregnant womens bodies build a cell layer around a developing fetus to protect it from toxins in the mothers blood.

The new HERVs are part of the family called HERV-K. The intact whole viral genome, or provirus, just found was on the X chromosome; its been dubbed Xq21. Its only the second intact provirus found to be hiding in human DNA.

In the researchers own words:
This one looks like it is capable of making infectious virus, which would be very exciting if true, as it would allow us to study a viral epidemic that took place long ago, says senior author and virologist John Coffin, Ph.D. of the Tufts University School of Medicine. This research provides important information necessary for understanding how retroviruses and humans have evolved together in relatively recent times.

Many studies have tried to link these endogenous viral elements to cancer and other diseases, but a major difficulty has been that we haven't actually found all of them yet, says co-first author Zachary H. Williams, a Ph.D. student at the Sackler School of Graduate Biomedical Sciences at Tufts University in Boston. A lot of the most interesting elements are only found in a small percentage of people, which means you have to screen a large number of people to find them.

This is a thrilling discovery, says co-first author Julia Wildschutte, Ph.D., who began the work as a Ph.D. student in Coffins lab at Tufts. It will open up many doors to research. Whats more, we have confirmed in this paper that we can use genomic data from multiple individuals compared to the reference human genome to detect new HERVs. But this has also shown us that some people carry insertions that we cant map back to the reference.

2017-02-17_075955

U-M genetics researcher Jeffrey Kidd, Ph.D., worked with Wildschutte when she was a member of his laboratory team. These are remnants of ancient events that have not been fixed in the population as a whole, but rather happened in the ancestors of some people alive today, Kidd says. There have been a number of examples of other HERVs that insert themselves next to human genes or near them, and have impact on their expression. Were interested in applying these methods to find other types of viral or mobile element insertions.

Genetic teamwork
The Michigan team used methods for characterizing repetitive DNA sequences that Kidd and his team had developed, while Coffin and Williams used complementary techniques. Wildschutte is now at Bowling Green State University.

Many of the genomes they examined were from the 1000 Genomes Project, an international collaboration. Another set of genomes came from work Kidd and colleagues at Stanford University had done as part of the Human Genome Diversity Project, with a focus on DNA samples from African volunteers.

These latter samples showed more signs of HERVs, in line with the high level of genetic diversity in African populations. That diversity stems from the longtime stability and intermixing of the continents population – as opposed to other populations in Europe, Asia and the Americas that stem from specific out-migrations in ancient times.

Cataloging all the HERV insertions in humans will require even more scanning of whole human genomes, which are becoming easier to come by as technology improves and becomes less expensive. And although intact proviruses lurking in our DNA may be rare, the impact of other HERV sequences on our health or disease is probably not.

The research was funded by the National Institutes of Health (OD009154, CA089441, GM112339) as well as the American Cancer Society and the F.M. Kirby Foundation.

ȸ University of Michigan Health System

ϾǶʪ֥ޥॷ׺ٶݤ俢ʪʤɤطΤʤ̿Τ̤DNAƤ뤳Ȥ

ޥॷ̤γDNAðۤѵΰˡ

2015ǯ1126()155ʬۿ
 
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AFP۸Ǥʤۤɾˤ⤫餺˶ѵޤ˻Ƥ뤳Ȥ餽̾Ĥ줿֥ޥॷפٶݤ俢ʪʤɤطΤʤ̿Τ̤DNAƤ뤳ȤȤ븦̤ȯɽ줿ΡֳװҤϡޥॷˤƲʴĶӤˤʤäƤȤ

ʤݡưʪȤƤФ륯ޥॷϡ©Ĺ̾0.5ߥۤɤǡ8ܤεӤǤäԴѤ⤯ĶŬϤ˹⤯üʲٲǤ¸ǽޥʥ80٤ˤ10ǯ줿Ǥ⡢फ20ʬˤϺƤưϤ뤳ȤǤ롣

ޥॷΥΥˤɤƥΡ饤إڥҥ빻University of North Carolina at Chapel HillˤθϡΤ6ʬ1᤯17.5󤬰ۼ̿Τͳ褹ΤǤȤäλ¤ȯȾưʪ˴ؤƤϡΥΤdzDNAͳ褹Τγ1ʤ

23ƲʳإǥߡסPNASˤ˷Ǻܤ줿ʸζƱɮԤǡΡ饤綵ܳΥܥ֡ɥƥBob Goldstein˻ϡֿ¿ưʪҤƤ뤳ȤΤƤۤɤٹ礤ǵȤϻפʤäפȽҤ٤

ʲ˴ؤ뿷θ

θǤϤޤDNAɤΤ褦˷Ѿ뤫˴ؤѤä¤⤫Ӿ夬äɥƥϡޥॷ6000γҤƤ뤳ȤȯʬϺٶݤΰҤä¾ˤ⿢ʪࡢźٶݤñ˦ʪΰҤ⤢ä

ɥƥθ漼˽°θǡʸ1ɮԤΥȡޥ֡ӡThomas Boothby˻ϡֶ٤Υȥ쥹Ѥ¸ǤưʪϡҤ뷹ä˹⤤ǽ롣ƺٶݰҤϡưʪҤ⥹ȥ쥹ѵǽϤ⤤Τ⤷ʤפȻŦºݤˡٶݤϿǯδ֡ϵ˲ʴĶȴƤƤ롣

ޥॷϡҤΡֿʿšפˤäƳҤ롣ϡDNAƤѾΤǤϤʤʪ֤ǰʪ򴹤뤳Ȥؤ֡ӡϡְҤοʿŤϤ깭졢Τ褦ˤʤäƤƤꡢʲȰʪηѾΥΰˤĤƤμѤĤĤפȸ롣

DNA̵٤˥Υ˼ޤȤߤ뤬Υ˻Ĥ뤳DNAΤǡޥॷ˲ʴĶǤ¸ǤΤȤ

ˤȡޥॷDNAϡ٤δ֤ʤɤζˤƶȥ쥹ˤ餵Ⱥ٤Ҳ롣˦˿ʬ᤹ȡDNAǼƤ˦ˤȺ˦ϰŪʪ̤䤹֤ˤʤꡢʬҰʳ緿ʬҤưפ̲Ǥ褦ˤʤ롣˦ʬ᤹ˤĤơޥॷȤҲDNAƱ˳DNAޤ졢ۼ̿ΤŤҤΡ֥ѥåפ롣

֤äơ̿Ρط٤ˤĤƹͤΤǤϤʤ̿Ρإ٤䡢ޤޤؤȲǤʪͤ뤳Ȥǽˤʤפȥ֡ӡԽ AFPBB News

ȸ ƣС


ưʪ֥ޥॷס֤Ӥ

2008ǯ0914 22:58

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914 AFP۾̵ǡʤऻĤưʪ֥ޥॷפӸ򤦱֤ľܤ餵ƤӤȤʸƲʳػ֥ȥХCurrent Biologyˡס99ˤȯɽ줿

ԤäǥΥꥹ󥹥ءKristianstad UniversityˤIngemar Jonsson᤬Ψ븦ˤȡ֤ưʪ¸¸dzǧ줿ΤϺ󤬽ƤȤ

ưʪȤƤФ륯ޥॷϡ8ܵӤĹ0.1-1.5ߥꡣ600郎¸ߤĺ鿼ޤϵΤ©뤬äϰ䥳餹Τ¿

ޥॷϡޥʥ272151ʾβ٤¸Ǥˤ⶯ǯ֤δˤѤ300ΰϲǤӤ뤳ȤǤ롣

ϡǯ9Ǥ夲줿赡ءEuropean Space AgencyESAˤο͹FOTON-M3פ˴礵ޥॷ褻ޥॷϾ270εƻǡۤƼϤʤӸ򤦱֤ľܤ餵줿

ޥॷϵä塢ԤϤ¿βʴĶӤȤǧˤϾ1000ܰʾ嶯ʻ糰ӤƤʤʤäΤ⤤ޥॷϵ嵢Ը̤˿Ȥ

ޥॷ糰Ѥᥫ˥ʬäƤʤˤȡ֥ޥॷ˶Ƥ˦٥λȤߤŪζ˴ؤäƤǽפȤ(c)AFP

ȸ ƣС


ߤϥޥॷΤäƤ뤫mmʲʪǤˤ⹴餺X糰30012-0ޤѤȤ̿ξQ路ðۤ̿ΤޥॷΥڥꥹ-ä˼򷹤Ƥߤ褦

Tardigrades or "Water Bears" are the only creatures that can survive the extreme conditions in the vacuum of outer space.




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ΤޤޱιԤ򤷤ƵäƤϾǶʪǤ⡢Ѥ줿鴥礬ݤƤʤΤDzˤϼ夤⡣

㴥̲ץȥӥ
ޥॷʤɤưʪʤɤθĶФơưߤ̵վ֤Τ-ʬʤɤ뤵褷Ƴư򳫻Ϥ롣

ץȥӥ̵դε̲֤ΤȡưʪϥץȥӥˤäƴĶ-ФϤġϤ礷ƤΤ̤îˤʤꡢդۤ-ߤƴ̲ʤߤˤȸƤФ륯ץȥӥξ֤ΰ롣

îtun-ȸƤФ봥̲ΤϡΤ褦ʲʾˤ餵줿⡢ͿкƤư-뤳ȤǤ롣ϴ̲Ǥ郎̲Ƥ˸¤뤳ȤǤäơ-ƤΥޥॷबˤǽϤĤ櫓ǤϤʤư뤳ȤǤ-ȤǤäơθ̾뤫ɤϹθƤʤȤ-ɬפǤ롣

̲֤ˤϽִŪˤʤ櫓ǤϤʤ֤򤫤Ƥäȴ礵ʤ-ФäʤǤޤ֤ˤʤȡΥ륳ȥϥ˺-Ѥƶ˸¾֤롣

ʬȥϥ֤äƤȡαդΥޥǴ-٤礭ʤ뤬ߥήưϼ줺ʪȿú岽ʪ¤-˲뤳̵ȿνԤ˦ηĤƿ¿ͷΥ夬-ƼȻǤդߤޤꡢʵ̲֤ˤʤ롣

▪ : ̾νŤ85%򤷤ʬ0.05%ޤǸ餷٤δ֤ˤѤ롣
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▪ ֤ľܤ餵Ƥ10¸ƤȤȯ졢ưʪǤϽơ



س֥ޥꥺפԻ׵ġפҤǽ褿֤פλҤǤʤäȤȯ

ڶðۤΰҳء顢ۻƤ!! ¾Ժ˦֥ޥꥺפβ

2015.10.28

⤷ҸˤäƻҤɤƤ̤ˤȽ顢¿οͤϺʤѤ򵿤ۤȤɤξ⤷ʤ˵ˤΤ褦ʻ¤ʤˤ⤫餺ҤɤʪŪƤ̤ˤˤʤäƤޤȤǤϡʤΤ褦ʻ֤ΤʪŪƤϰïˤʤΤ ܺ٤ˤĤƤ褦

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֤ȷշޥåʤ!!

26ơBuzzFeedפϤȤʣγǥ󤸤ȤˤȡޤҤΥƹ亮ȥ󽣤ǵƤ2014ǯ6ƿ̾ؤΤȤ1ͤη򹯤ˤ֤֤ηշΤäؤδӤϰ֤ˤƺǤѤ롣ʤȡ֤ηշξƤηշȥޥåʤäΤ

͹ˤǥäᡢؤϤޤ±Ҥ㤨줿ǽ򵿤äΤ褦ʻ¤Ϥʤ뤿ᡢեؤΰؼԤǤХ꡼ΤΤȤؤȤä褿

ǤξƤ˻äƤͻҤǤסʥΡ

Τϡޤ줿֤ΰҤܤȡ֤ʪŪƤפϿ²Ǥ뤳ȤȽ롣ơޤޤ𤹤ؤˡΤϤ줬ˤ֥ޥꥺפ̤Ǥ뤳ȤοΤä

س!! ֥ޥꥺפԻ׵

̾ʹ֤ξԤѤ2åȤDNAäƤʡΡסˡȤ˥ȥʤǤ󤸤Ƥ뤬֥ޥꥺפȤݤǤϡ˦ˤͳΰۤʤҤޤǴޤޤ뤳ȤˤʤʤĤޤ2åȰʾDNAѤȤˤʤˡθ夷³롣ޥꥺˤäξưʳͳ褹DNA͡ʥˤϡΤȩο䡢ǰۤʤ뿧򤷤ܡˤ2ĻäޤƤʤɤγŪħ򼨤Ȥ롣ޤǤ100ۤɤ𤵤Ƥʤޥꥺ͢¡ܿƤȤۻδ֤ǵ뤳ȤΤƤꡢºݤȽƤʤȯ٤Ϲ⤤ΤǤϤʤȤλŦ⤢롣ޤ٤κ졢8ͤ1ͤDz餫ΥޥꥺबƤȹͤȤ⤤褦

2015-10-31_053437

֤󡢼¤лҤä

Ǥϡ亮ȥ󽣤֤ϰΤɤΤ褦ˤ3ԤΰҤ줿Τ ¤顢ؤλҤɤлҤäȤȽƤ롣ǥǽʳǰˡĤä⤦˵ۼȹͤȤ

Τ褦ʸݤϡ֥Х˥󥰡ĥʾǤҤɤˡפȸƤФ졢褷ȤǤϤʤΥǤϡεۼ줿лҤΰҤۼ¦Ǥ⤦лҤĹˤ礭̤ᡢ̤ȤʪŪƤϤΡȾǤҤɤɤˤʤäΤĤޤꡢ֤ʪŪƤϡΤ礦äȤ櫓

ξƤηշƤʤȤƤηշOƤηշABξ硢ޤҤɤABȤʤ롣лҤ줾ABäȤ褦⤷⺣󡢵ۼ줿¦лҤAȤȡۼ¦ˤȤäƤʪŪƤAƤOȤȤˤʤ롣AOδ֤ˤǤҤɤϡAOBǤäϤεۼ¦OȤޤƤȡؤȷշޥå󥰤ʤ֤Τ

Υϡ֥ޥꥺפˤäưҸ줿ΥȤʤä褦ʤߤˡܸݤˤĤƤϼ㤬ʤӾǤ뤿ᡢ֤褯狼ʤ¿ĤƤ롣ˤƤ⡢ޤޤΤˤϻ䤿Τʤȿ뤬Ƥ뤳Ȥϴְ㤤ʤ褦ŸڤߤԤȤ

Խ

͡BuzzFeedסMedical Dailyסۤ

ȸ TOCANA


פҤǽ褿ҤפλҤǤʤäȤƹȯ

2015ǯ1029 1736ʬ

2015-10-31_053351

ƹ亮ȥ󽣤˽ޤ줿椬ҤΰҸ򤷤ȤʪŪˤܿͤλҶǤϤʤλҶǤ뤳ȤʬäȤ

ҤϳΤܿͤΤ
34ͤϡʤȤȤǥŤƤꡢޤ줿ҶϿ͹ˤΡ

ôϿ͹˻ѤҤܿͤΤΤǤ뤳ȤǧƤ롣ˤ⤫餺ޤ줿ҶηշξƤΤɤȤפʤäᡢ׺ʤϰҸꤷ

ҤϷΤ
դפñդμ褷ҤĴ٤ȡҶΤΤȤޤääƤĤޤꡢ100%פλҶǤϤʤ

ȤפҤĴ٤ȡ10%ȤȾüʳ礬ҶΰҤȰפϡŪˤϡפη郎ƤǤȹͤ롣

ԲIJʤȤˡפ˷ϤʤΤ

פ˵ۼ줿лҤΰ
Ϥʤ븡Dz򤱤פϡʪŪˡ֥פȸƤФ졢ޤäƤǷοΤۼη̰ͤޤƤȤȤʬä

Ĥޤꡢۼ줿κ˦Τˤޤꡢ줬ҤäƤȤˤʤ롣

֤ˤϰؼԤӥåפȡҸԤʤäƹ񥹥եؤΰؼԥХ꡼ϸ

ŵMan finds out absorbed twin is genetic father of his child - UPI(10.27)

ŵHow a Mans Unborn Twin Fathered His Child - TIME(10.28)

ȸ IRORIO

ܤޤŪʸ楰롼פ缺Ĵɡפȯɤ˴Ϣ108ĤΰҤ

缺ĴɰңĤ

2014/722 2118ʬ

19-26

ܤʬäƤʤ缺Ĵɤȯɤ˴Ϣ룱ĤΰҤꤷȡܤޤŪʸ楰롼פȯɽ缺ĴɤοʼγȯˤĤʤΤȤܤƤޤ

缺ĴɤϡФۡ˰ߤ̵ʤʤɤξɾФơ褽ͤˣͤȯɤȤޤܤʬäƤޤ

缺Ĵɤȯɤ˴ϢҤʤƤܤ䥢ꥫʤɤʾ塢ͰʾθԤǺ륰롼פϡޤǴϢŦƤңĤȡʰңĤι碌ƣĤΰҤȯɤ˴Ϣꤵ줿ȯɽޤ

楰롼פܤͣ컲äƤ롢θ˭Ԥˤƣݷذδˤޤȡθϡܿͣ;ޤ缺Ĵɤδԣͤȡ缺ĴɤǤϤʤͣͤΰҤϤ̤ˤΤǤ

ĤΰҤΰäƤͤǤϡ缺Ĵɤȯɤꥹܤ飱ܹ⤫äȤȤǡβϷ̤ҤˤĤʤäȤȤǤ 缺ĴɤμϡޤǣĤΰҤΤĤƯѲƤ餺θ̤ϿʼγȯˤĤʤΤȤܤƤޤ

ĶϡֹǤ⣲ͤƤ缺ĴɤˤĤơ֤βʤߡʼγȯ­ˤʤ뤳ȤԤǤפäƤޤ θ̤ϡꥹβʳػ֣ΣפŻǤ˷ǺܤƤޤ

ȸ NHK˥塼


Ư̤ͭΤϤäݤ ŪŪ׹ͤäƤΤ⡢ɤȤ缺Ĵѡʥƥ㳲

缺Ĵѡʥƥ㳲 - Wikipedia

1ϡطǰθν̤ʰ̣Ť򤹤뤬οäƤطۤϤǤϤʤ

2ϡʸϤΥ줿̯ʤ뤤ŪʿǰꡢƥѥͽΤʤɤǡñʵȼȤ⤢롣

3ϡ̵Τ褦˴Ȥ褦ˡγФƤ礬롣

4ϡۤäϡ˶ŪǤäŪǤäꡢ̤ȤϰäǸդѤꤹ롣

5ϡʹǰʬ٤褦ȤƤΤǤϤʤʤɤȹͤ롣

6Ŭڤޤϸꤵ줿ϡɹпʹطݤĤΤɬפʤȤ򤦤ޤʤ

7ϡ̯ʤ䳰Ѥϡ碌ʤäꡢ餷Τʤ뤤ϱ줿ʤɤħĤȤ롣

8ϡ²ʳˤޤäͧͤʤ

9ϡʼҲ԰¤ϡˤäƸ뤳ȤϤʤŪʶݤˤäƤǤ롣


ꥫοǴDSM4ˤ˽ССۡβáĥưɾΤ줫İʾ򣱥ʾϤ褹뤳Ȥɬ׾ ˤʤäƤ롣

οǴˤ ˡ缺Ĵ;㳲û¾㳲Ĵ㳲㳲ж㳲 ʤɤꡢ֤δ ֡㳲̵ͭʤɤǶ̤Ƥ롣

οǤɸǰդǤ̤ȽǤΤǤäơ褷ʪŪ Ūʺ򤬤 ΤǤϤʤΤ褦ˡ缺Ĵɤϡ֤Ϣ³Τðۤ ǤȤϡ¾ɸΤҤȤĤζʬǤȹͤۤ ⤷ʤ

¤ʬǤϤޤ­ʤơʾܤɤǤʤΤ褦ʲʤ ¾οͤʹʤΤ褦ܿͤǧΤ뤳Ȥ⤢С軰ԤƱ˳ǧǤüʪݤȯ뤳Ȥ⤢롣 ȯΤˤäƤνȰ㤤狼ʤȤ⤢뤷狼æƤ⤢롣

빾ǽԤͤ±ˤͤ⤤롣ǽԤ򿮤ͤϡȸä±ؤǤϸФȸäꤹ롣ԤŪʸݤȤ뤬˳˸븽ݤ⤢ΤǡؤԽʬΤޤ޵Ƥ뤳ȤüŪˤԤ錄ɤ줬äˡȿǤƤ롣

ֳ줿á եɤˤ¼Ťؤإץ (Open Dialogue, Japanese subtitles)



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