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STAP˦θ漼ES˦ޤ줿Ȥ뷺ȯ򻲹ͿͤȤǤդǻİ

򻲹Ϳİ衡ES˦ȯ

2016/02/18 05:50

2016-02-18_082702

STAP˦ꡢظθ漼ES˦ޤ줿Ȥ뷺ȯʼ˸٤һ˻ͿͤȤǤդǻİƤȤʬޤ

ǯ1ͻԤظθ漼鲿ԤES˦ȤơOBƵԾܤƵιȯʼ˸٤Ф٤ǯ5˼Ƥޤ

ܺطԤˤޤȡʼ˸٤17ޤǤˤٻδطߤǡᤫ黲ͿͤȤǤդǻİȤȤǤSTAP˦äƤϤȤȤ12ĴѰ񤬡STAP˦ES˦ͳ褹ΤǤפȯɽƤޤ

ȸ ƥī˥塼



2016-02-18_082722

2016-02-18_082736

2016-02-18_082744

2016-02-18_082755





STAP˦ư۾ҡֲԤES˦櫤˥ϥ줿

®۾ҤܤǡֲԤES˦ƻϥϥ줿

2016ǯ127

and_553169

STAP˦¤Ǥ֤ɤ¸ߤ뤳ȤǤʤޤ࿦ҤܤǤ뤳ȤʬäamazonͽˤʤäƤΤϡ֤פȤܡɮԤϡ־ҡפȤʤäƤ롣

ҤϹ̼ҤȯǡŻҽҤȤɤKindleܤȤʤäƤ롣Ĺϻܤ˴258ڡ̤ϾʤᡣˤʤƤϤȤȡԤ֤ȤSTAP˦ưˤĤƾλ֤줿ŤʰȤʤäƤ롣ܤϸͽȤϸʤҲʸ򸫤ȡ櫤ˤϤ줿פȤǽ񤫤Ƥ褦

ӣԣưοꡢ̿ʳس롢ȲФ˾Ƥʹ֤̤֤ä׷μ국
Ԥؤ̴ܥȥΥݥץڡե˦ ޥ롡륹פȤΥƤ桡ʸԴ֤ξ͡Ϥ뤫Ķȿϥϳ줿οʤäΤ10 ǥࡡ11ʸű12Ȥޤ줿ţӺ˦ȡ꡼13Ȳetc.



ܤ٤12ϤΡֻȤޤ줿ţӺ˦ȡ꡼פԤδ֤ǤϤθĴǾҤSTAP˦̾դΤES˦Ǥ뤳Ȥ餫ˤʤä12ϤϤλ¤ƧޤơïES˦Τȿͤ仡ΤǤ

ʤnetgeekǤϰƱ漼AҤ㤤ES˦ƤޤܤΤݤۤäƤơθϤۤФߤʤ鴪㤤޾ФäƤפȤȡ꡼ŸƤϤʤְ㤤ǤϤʤΩƤäΤǤϤʤ

͡Ҥ٤줿AҤ΢ȡ꡼STAP˦ϻΥߥޤ줿ۤʤǤ

ҤϺǸޤSTAP˦Ϥȸ³ƤνҤǤES˦äȤȤǧƤ롣

stap_obokata4

ƻ륫֤ǤκǸκƸ¸Ԥ˽äƤ⾮Ҥϡ֤ǤSTAP˦Ϥ롣̤줿©ҤΤ褦¸ߤʤΤǤĤɬĤƤߤפȼĥƤSTAP˦μ¸˲٤Ȥڸű󤷤ʤäˤ⤫餺ˤơ֥ϥ줿פȸФΤϲ꤬뤫ʤΤ

ͤϻ֤ФĤ͡ʴ졢ҴŪ˼ʬߤ뤳ȤǤ褦ˤʤȤ

obokataharuko_ura

ǤˤäƾϤޤϤ֤Ǥ򤫤ȤպᤷζȤΤϲäΤܤӤˤϡֿ¤Ĥ᤿ΤïפȤʸ礭ʸǺܤƤ롣

ȸ netgeek


국ǡӣԣưֿ¤񤳤ȷ᤿

2016ǯ128 05:30

2016-01-28_155538

ӣԣк˦ʸԤäظθһʣˤμ국̼ҤǤ롣᤬࿦塢ޤȤޤäĥ򤹤ΤϽơ֤פꤷƱǡϢưˤĤơֿ¤񤳤ȷ᤿פȼɮưˤä¸ߤꤵ줿ӣԣк˦˼ºߤ뤫ɤˤĤƤϿƤʤ

餬Dz񸫤֣ӣԣк˦פȯɽΤǯ֥ꥱפȤưοͤˤʤä礦ɣǯܤ˹碌Ĥۤˤä

񤭤Ǥϼɮư֤Τޤ޸Ĥߡ֤˺ƤΤԤĤȤϡʤҤ礦ƨȻפ¤񤳤ȷޤפ̼ҤˤСơؼ국ơƱҹ󼼤ϡԤθɽ뤳Ȥϡӣԣк˦ᤰ뺮θξǰյȹͤƤޤפȤ

ôԤˤС᡼á̤Ǥ碌Ťͤ󣴥ƺǯ˽񤭾夲̳ͤ뻰ڽ۸ΤϡܿͤĴǡä¤񤤤ܤǤפȥȤ

국ϣӣԣк˦ˤĤơٶǤäȤ򡢿ȿʤѤƤޤפȼպᡣ᤬Ԥ֤ϤޤꡢϢưڡϹǤĤŤäƤ롣

ϡֻȤޤ줿ţӺ˦ȡ꡼פϡǯˡֻȤ˻ΩƤưäȻŦԤǸμ㻳ɧ綵䡢̿ʳظ楻󥿡꼡Dz񸫤򳫤᤬ţӺ˦Ȥäƣӣԣк˦¤ʤͤĤˤ褦˲ȼĥƤ롣

ưαˤäǯ˼ʤκ˧ˤĤƤϡϡֶȲСפǡֺˤʤää϶ȲФ˾Ƥ³̵ʪˤʤäפȥå礭ɽڼ¸ˤϡνŤޤȤ

֣ӣԣк˦ϤޤפǸƱǯβ񸫤΢¦򡣲񸫣Ĵɤ񸫤ơ±ƱȱڤäƤäƤ桢ƻդ齵ϤƤ줿Ūˤ夷ƤϼȤμ̿ܤäɽ򸫤Ƶ䤷Ȥ

ƱǤϣӣԣк˦ˤΤɤȤ˿ˤϿƤʤߤꤸ줿Ĵǣӣԣк˦¸ߤꤵ줿ȿǤ꤬dzǽ⤢롣

ǵǰ񸫳̼Ҥˤȡ֤פϽǣǣߡ̡ˡǤ˴ؤƾ᤬Բ񸫤򳫤ͽϤʤȤŪԤؤΰǤ󣱣Ȥߤ졢Ƿ׻硢μ긵Τ󣷣ߤˤʤ롣

ȸ ݥ˥




ҤSTAP˦¸ߤ롪ƸԤʪŪʥȥ쥹Ǻ˦STAPݡ׳ǧϥǥޤä

STAP˦¸ߤƤȤʸͥ㡼˷Ǻܡעͼ¤ϥǥޤǤڤäư

2015.12.12 21:38

2d03f5a9-s

ҤȯϿ¤äͥ㡼˥ޥκ˦¿ǽġSTAPݡפꥫθԤˤȯɽޤ


2015ǯ1210

Ҥȯֳȥ쥹ˤκ˦¿ǽġסSTAPݡפ¸ߤ𤹤ʸʳػ֥ͥ㡼פλǥ饤ΡNature.com SCIENTIFIC REPORTSפˣǯդǷǺܤ줿

Characterization of an Injury Induced Population of Muscle-Derived Stem Cell-Like Cells »ͶƳˤͳδ˦ͺ˦iMuSCs

Characterization of an Injury Induced Population of Muscle-Derived Stem Cell-Like Cells

ʸμưͭ

ڲΥȥ쥹ˤκ˦¿ǽSTAPݤƱ̡

Ǥޥιʶڤ鴴˦ˤʤ뿷κ˦ĤȯȤ롣 ʪŪȥ쥹κ˦졢¿ǽġפȤSTAPݤƱƤ롣ޥ¸Ǥ⤳κ˦¿ǽѲ¿ǽ˦Ǿ١¡ˤGFPǧ줿Ȥλ

ں˧Τζäϴ˦ؼԤȤä

κ˦ʪŪװ̤ʬξ֤ꡢ¿ǽĺ˦Ѳ롲Ρֻαդ˿륹ȥ쥹ˤ˦̤ʬξ֤ꡢ͡ʿΤȿʬǤ¿ǽ˦ˤʤ׻STAPݤ̾դ̤Ʊȸ롣

ɷˤꡢκ˦򴴺˦˽ȤSTAP¸ˤĤƸκ˧Ρʵǯˤϥͥ㡼εԥǥӥåȻˤä餷̤Ǥ伫ȡΥȥ쥹˦ˤΤ褦ʸ̤⤿餹ȤϻפäƤߤޤǤפζääΡ٥޵θԤǤ⡢פʤ̤Τκ˦֤ȯƤΤ

ھҤȯϿ¤ä줿

ҤϺ˦桢˦˥ȥ쥹򤫤ʬ¿ǽĤ褦ˤʤ륢ǥ⤫ȤΥͥ㡼ǾΥǥܶڤϴְäƤʤä줿Ϻ˦˥ȥ쥹򤫤¸դǤϤʤ˦˷򳫤ˡʪŪʤɤ¿ǽޡȯ褦ˤʤä𤷤Ƥ롣

STAP˦ƱʪǤϤʤSTAPݤȤ˦νϾ줿

ʪŪǺ˦¿ǽĤȤ븽ݤ𤵤줿ˤꡢ˦ץߥ󥰤롢Ȥäֺ˦Ϥäʬ̤ʬξ̵֤˦ʬʤǹԤסκ˦̤ʬ˦ˤʤꡢ˦֤Ȥƿȿ褦ˤʤʤƻϤʤפȤSTAPɤϤμ¸̤ɤΤ褦ªΤ

ʸ˰Ѥ줿ʸ

ϡСαػ˽񤫤졢֥ƥå塦󥸥˥󥰻פ˷Ǻܤ줿The Potential of Ston Cells in Adult Tissues Representative of the Three Gern Layers κ˦¿ǽĤ褦ˤʤ븦椬¸ʳǤ򼨤˰ѤƤ롣ιͿˡ¿ǽ˦ˤĤƽ񤤤ʸήθãλͤˤʤäƤϤʸ򸵤ʸ񤤤ְäƤܤؤФˡˤذ̤μͿפȽꤵ졢ذ̤å줿

ոۤԤޤ̿ġޤߡ <mjp@mbr.nifty.com>

Ϣ֥̿STAP˦ʸĴѰ𡢲װؤκŪ

81bbfe5b

ڥͥ㡼ʸܸ

Abstract

桹ϺǶᡢޥʶڤδ˦οʽĤȯޤνͶƳζͳ贴˦ͺ˦iMuSCsˤʬŪʬڸ˦ƥץप¿ǽΤ褦ʾ֤ɽƤޤΤ褦ʿӶڸʬʤɤʣηʬǽϤޤiMuSCsŸ˦;Ϥޤin vivoǤζζϤǽϤ¾ڤͥ줿ܹ̤ɽޤ

IMuSCsˤϡĤ¿ǽӶڸ˦ޡȯޤεڤӴǽϤͭ3ĤΤ٤Ƥդʬ뤳ȤǤޤޤ˦Υޥ󥸥ϡiMuSCs˹׸ãλǤʤäȤ򼨤ޤ桹η̤ϡiMuSCsʶڤĶˤä줿¿ǽʬŪ˺ƥץव줿֤Ǥ뤳Ȥ򼨤Ƥޤ

IntroducionƳ

»ȿϡȿΤӴ˦γӶɽꤪȤο˱˦ο¿ޤʣʪŪץǤӮưʪιʶڤκˤϡݤδȶں˦δ֤˰֤ñ˺˦νĤǤ˦ȶ˦MuSCsˡʤɤξcells1,2γ˰¸Ƥޤ

MuSCsϡ˦εǽŪԶѰʽĤǤꡢ®١ޡȯץե롢ʺǽϡʬcapacities2,3äƤޤ桹ϰMuSCsiMuSCsξĤ¸ߤ뤳Ȥȯ桹laboratory4dzΩCre-loxPƥѤ»ޥιʶڤñΥ뤳ȤǤޤ

桹iMuSCsϡCD34ȯSca1ʺ˦-1ˡPAX7ʥڥܥåѥ7ˤǤʤvivo5˶ڸʬӶκǽϤ󼨤ǤʤȤƤޤ

ˡ桹iMuSCsϡ˦εư򴴼¾ڤΤ褦muscle4ˤCD31 +ͺ˦ʤɤڸʬ뤳ȤǽǤ뤳Ȥ¾ڤޤǤϡˡη֡ޡȯץե롢¿ǽϤĻǽϤʬǽϤ˾ơiMuSCsͭĴ٤ޤ

Results

桹γΩ줿˦ʬΥˡʿ1aˤŬѤ뤳ȤˤiMuSCsޥTA˶ڤñΥޤ塢˦ñΥ塢iMuSCsζں˦Ĥ0.1ˤܻ˸ޤ˦ϡоȤΩ줿ʪ¸ߤƤʤ̵ζʿ1bˡɾϡɽiMuSCsϡľ5-7ߥǤäŪ礭ʳˤȺ˦ζबޤޤƤ뤳Ȥ餫ˤʤޤ

γˤMSX1MSHۥᥪܥå1˼­S1aȡˤȥإ33342Ӽޤ줿BrdUʥ֥ǥꥸˤȤʤޤPAX7ȤSca1ʿ1cˤȯ뾯κ˦ǤäΤ˦ñΥޤiMuSCsνο͸MSX1CXCR4CXC⥫Υ4ˤγ礬⤤ޤޤƤޤ

TAΰȯʬϤϡMSX1ʤޤPOU5F1ȸƤФˤOct4Sox2̵Ťڡʿ1d­ޤӤƥåץ쥮졼ȡSRYܥå2ˤNanogȯޤS1bˡñΥiMuSCs϶ڸ˦ϢޡʤSca1PAX7CD34ӥ¿ǽޡҡʤOct4Sox2ΤNanogȯʿ1Eڤ­ޡS1cˡ

iMuSCsϡ13֤ʿѤκ˦Ĥܲû֤ͭĹin vitroޤ˦ŪϤϡiMuSCsʽ˷äƤȤ餫ˤޤΰ۾ϡ5­S1DˤΤΥȥ꥽ߡǡη̡Ĺܡʷ33ˤδ֤˸ޤ

ޤiMuSCsޥ졼ͭƤȤȯޤץưåΥǡϡiMuSCsоȥޥڲ˦C2C12٤Ĺ⤤®٤ȵΥܹԤƤ뤳Ȥǧȥ뤫ʬΥMuSCsϡʿ1F˶̵ޤiMuSCsmRNA٥ʿ1GˤǦ¥ƥ˥󤪤ӤĤΥɥإ٥ȯޤ

γ¿ǽʬåiMuSCsMyHC +ʥߥźMuSCsC2C12ڲ˦ʿ2aˤƱͤͻ祤ǥåĶʬǶڴɤͻ礹뤳ȤǤȤ򼨤ޤ iMuSCsBMP2ȹι­S2ˤʬ뤳ȤǽǤ

iMuSCsñĸŪˡ콵֤Τ˿д˦ϡˡ򻲾ȡˤǰܥ˥塼եη𤷤ƿͶƳ뤳ȤǤʿ2bˡ켡ڲ˦MuSCsϤι¤򼨤ޤǤ iMuSCsˤäͶȯ˥塼եϡɽ򼨤ͥCNPNefmʥ˥塼եȡˡʿ2bˤɽޤ

3ָ塢ʬϤ˥ߥ˥/ݥꥪ˥󥳡ƥ󥰤ñܤǥåƥ˥塼եϡĤμפʿзʥ˥塼󡢥ȥȡӥꥴǥɥȡˤʬ뤳ȤǤMtap2ɽ¥塼֥IIINefm ͥ󤪤Olig1 / 2ʥꥴǥɥž̰1/2ˡʿ2BC

iMuSCsεĴ٤뤿ˡ桹ϡin vivoܿǹԤޤ iMuSCsMuSCsƱΤ6 6-8ͺmdx / SCIDޥʥ㥯󸦵ꡢƹˤTAڤͤޤ󻰽֤κ˦ܿ塢桹ϥۥȤTAΥ桼ȥեȥȥեʿ2dˤȯ򸡽ФiMuSCsMuSCsʿ2dˤӤơ礭궯Ǥʥȥե+ܿҤƤ뤳Ȥѻޤ

桹ϤޤiMuSCsΰҵڤӥѥȯץե餫ˤ뤿ˡŪꥢ륿ݥ顼ϢȿqPCRˤȱȿʬϤԤ˦ESCˤӶڸ˦C2C12ڤMuSCsˤˤӤޤ iMuSCsESCΤƱͤˡB3aڤ­ޤS3aˤOct4SSEA1ʳðŪ1ˡSox2ΡCXCR4MSX1PAX7ȤSca1ȯ㤤ȯ٥ǡ

QPCRʬϤiMuSCsESG1ڤDAX1ʿ3Bˤơ¿ǽޡҤʬȯ뤳Ȥ餫ˤޤESCϰۤʤꡢiMuSCs϶ڸޡҤọ̇Ȥˡϸ˦Ϣޡΰ㤨Blimp1ȥե饸ꥹΤ褦CD45ޤCD90ʿ3cˤȤơ¾η˴ϢҤȯޤǤ

ޤiMuSCsϡ륫ۥեʿ3aˤФǤη̤ϡ餬ڸESCΤ٤ơڸҤ㤨Сȯݻ뤿ᡢiMuSCsϡ˻ƤޤESCΤƱǤϤʤȤ򼨤ưפin vitroǶڸʬ褦ͶƳ졢ǡˡ

iMuSCs¿ǽΤˤ뤿ˡ桹iMuSCs㡼ΡEBˡʿ3deˤ뤳ȤǤ뤳Ȥ򼨤in vitroǤassays6,7ʬԤޤͷܤ7塢EB礷ȯŪʬ򳫻ϤդռͶƳΤˤ2ܤ塢°EBϡФΤ褦ʹ¤¿˶ڴɤ̤ʿ3F Gˡ桹Ϥˡin vivoǴˤäiMuSCs¿ǽƤޤ 7֤SCID١ޥʥ㥯󸦵ꡢƹˤ˰ܿȡiMuSCsϡ90N = 7ˤϡ3Ĥդɽȿޤʿ4a˴ޤȿŪiMuSCsϡСӻȿӾʬ뤳Ȥ餫ˤޤ

ϡܿ줿˦ľܷ줿ȤǧˤϡiMuSCsϡͤ˦-galǻɸ桹LacZʿޤȤΤ٤Ƥ3ĤͶƳΤϡ-gal+˦ޤǤФ4b ˡ

iMuSCsϥޥ뤳ȤǤ뤫ɤɾ뤿ˡ˦åԤäʿ4cˡ桹ϡɸŪprocedures8ʲΥޥ󥸥ˤäƤBALB / cʥ㥯󸦵ꡢƹ˦̤ʬΦ-gal +ñ˦ȤƤGFP-ͽɸiMuSCsܤޤ

桹ϡ6Ŭڤ˳ȯ졢GFP + iMuSCsδͿ򼨤E148ޤ -galGFPȯ˦ι٤ι׸ϡE14Υʿ4cd­S4aǤϡˤǸ뤳ȤǤޤ ȿŪʬϤϡiMuSCsϤ٤Ƥ3Ĥաʿ4Eڤ­S4bȡˤ˴ͿƤ뤳Ȥǧޤ iMuSCs˦ͳ¹ޤ졢˳ȯޤμ¸3󷫤֤塢䤿­ɽS1ˤäޤ줿23ɤλҡ٤Ƥޤ

ʬȱiMuSCsɽޤǤãȱqPCRʬϤϡޡ㤨С桢¡١¡¡ǾʤɤλƤΤĤȿǤLacZ +GFP + iMuSCs¸ߤ餫ˤ4F­ޥƥåS4cˡ

Discussion

̷⤷̤͡groups9,10,11,12,13,14,15ˤä𤵤ƤΤǡȿˤ¿ǽ˦ͺ˦¸ߤϡǯ֤μȤʤäƤޤϡޤǡΤ褦¿ǽ˦ϡʬκ˦ȿ뤳ȤƤޤ

ܸǤϡ˦κƥץߥ󥰤ʶڤƤȤȯ붯ɷ㤹뤳ȤˤäƳϤ뤳ȤǤ뤳Ȥ餫ˤޤΤ褦ˡ桹ʶڤƥץवiMuSCsñΥ뤳ȤǤޤ

ޤȤȡ桹θϡiMuSCsޤǸ椵줿٤Ƥκ˦Ȥϰۤʤʷ֡礭Ӱȯץեˤͭ˦ΥˡʡҴʽĤǤ뤳Ȥ򼨤Ƥޤ

IMuSCsESCɽŪʤĤħɽʺ˦ζ˰Ϥޤ줿㤨緿ˡ⤤/˦桢ޥ¤˼ڤΤοˡɽ1ˤǤʤĤ¿ǽɽǤʤޡҤϡڸҤι⤤ȯ٥ݻޤ

ޤܸκǤܤ٤ȯiMuSCsϡin vitroin vivoǤ¿ǽΤδΤĤȤȤǤ桹ϡ˦Υޥ󥸥ãiMuSCs뤳ȤǤޤǤiMuSCsϡ¿ǽޡ㤤ȯץե㤨СOct4NanogΡڤSox2ΡˤͭȤESCӤ硢ESG1ڤDAX1ȯ礤ƤȤ¤˵ޤ

iMuSCsˤäƤBlimp1ե饸ꥹӶڸޡҤŪ⤤ȯδѻ˴Ϳ​​뤳ȤäȤ餷Ǥη̤ϡiMuSCs¿ǽԤ餯ζڸȿΥԥͥƥåʵݻƤʤȤ򼨤ƤޤΤ褦DNA顼ޤNanogβȯ˳ʤiMuSCsΤʤϡŪ˴¿ǽã뤿iMuSCsץå夹뤳ȤǤޤ

STAP˦ƻץƥκǿ

ǥޤȤǥޡSTAP˦Ϥޤ
ҤSTAP˦¸ΡȤäȤƻˤĤޤ

ҤȯϿ¤äͥ㡼˥ޥκ˦¿ǽġSTAPݡפꥫθԤˤȯɽޤ

BPOơSTAPƻפˤĤ
ֿ͸θ¤Ԥ ΤBPO͸ѤNHKڥƻﳲ򿽤Ωơ BPO͸Ѥꤷޤ

ȸ Ҥؤƻɵڤ֤ͭβ







εǤϸήƤޤޤꥫʸSTAP˦ꤹƤǤ͡ե֥å֥ξȽǤƤޤȡȤǤʤǥޤƤޤΤդɬפǤ

Τȯɽ줿ꥫʸΰǤSTAP˦θݤꤹ褦ʸդ⤢ޤϤޤǤθݤǡʸƤǧʪǤϤޤ

ե֥åǤ4000ʾ⥷ƤޤǥޤȵĤθƤӤ򤹤褦ˤޤ礦

εθպᤤޤϺޤǰʾ˾󸻤γǧϤ褦Ȼפޤ

ȸ ¤õ֥


STAP˦Ϥƹ˥ѥ줿 STAPݤȹiMuSCs˦

2015.12.14

2015-12-16_181252

ϥΡ٥޵ȯȤޤǸ졢STAP˦θŸϤ¸ΤΤȤǤ롣֥ꥱϽҡˤפȤƥޥǥ夲줿ҡظ긦32ˤϡʸ¤ǤιäФơ䤹äҲ񤫤鴳Ƥޤä

2015-12-16_181241

ߡ֥ꥫθԤSTAP˦¸ߤǧפȤSNS̤ƳȻȿƤǤ롣κϡʳػإͥ㡼٤αĤ륪饤Żҥ㡼ʥScientific Reportsס1127աˤǡƥذҥ塼ȥ󹻤ԥåĥСذθԤȯɽ

Characterization of an Injury Induced Population of Muscle-Derived Stem Cell-Like Cells»ͶƳζͳ贴˦ͺ˦ˡפȤʸȯͤƤ꾮ȯϿ¤ȼĥƤ֥־Ҥؤƻɵڤ֤ͭβפǤ뤳Ȥ䡢ʸºݤɤSTAP˦˾ƤǤϤʤȤ顢ξǥޤǤưⵯƤ뤬̤ƿϤɤˤΤ

äƤޤȡʸǾ᤬ȯȤSTAP˦¸ߤ줿櫓ǤϤʤΰǡԤϡ֥ޥμ褷κ˦˻ɷͿ»ˤȤES˦iPS˦Τ褦ˤޤޤʺ˦ˤʤ뤳ȤǤ˴˦ˡȻɺ˦ǤפȤȤȯɽiMuSCs˦פ̾ŤƤΤǤ롣

Τˡˡ̤ϾSTAP˦ȤϤޤäۤʤ뤬ʣʹФ뤳Ȥʤ˦ǽ˦ˤ˶ᤤĺ˦߽ФȤܤСθʤȤSTAP˦Ʊɸ򸫿ΤǤȤϴְ㤤ʤ

ĻͺȲʳإ饤ưˤĤƸä

Τ褦ˡSTAP˦ϤʤäȤƤSTAP˦ƱͤΤΤ߽ФȤʳس礭ưˤĤơ󥹥󥿡ƥʡĻͺϥȥʤ˼Τ褦˸ä

ֻϡư1ǯۤɤǡꥫSTAP˦Ȼ˦ΤǤϤʤȰȯƤޤϡޤǤΡܤȥꥫˤʳ٤ˤ򸫤餫ʤΤǤ

ֻ涵iPS˦ȯɽۤƱˡꥫΥ٥㡼ȤƱƤʸȯɽƤޤϤĤޤꡢꥫؤΥǡǤȤȤ̣ޤλ˵ؤȤä֤ϡꥫǺȽ򵯤ˤʤ뤿ᡢꥫǤõˡ衼åѤǧƤ餦褦˿ޤ餦ȤǤ

ּºݡƱ褦ʥϲˤ⸫ޤɽϡޤOSإȥ٤ǤȯԤܤ̵ۤڤߤޤꥫܤ˰Ϥ򤫤ơȥ٤зپʤˤʤإɥ٤ĤƥꥫˤܤؤΥץå㡼ϡ̮³Ƥ롣٤ƤΤʤΤǤ

֤ʤߤˡSTAP˦Τ褦ʴñʼˡǽ˦ǤǽˤĤơʳسǤϤäΤΤȤï⤬ǧƤޤޤ˴δܤǤꡢïǽ˸Ĥ뤫äƤΤǤ ֤ޤ2014ǯ˹ʸؤSTAP˦¸Ȥ⤢ޤ˶餬̤ꡣ⥢ꥫΰϤˤä٤Ƥǽޤ

ֺȯɽϡޤʤFakeǤǽݤޤ󡣤STAP˦뤤STAP˦Ȼ˦ɬꡢޤܤȯХꥫ٤ˤȤ¤ϳΤʤΤǤסĻͺ

Τˡؤλ濭ﶵؽī٤Υ󥿥ӥ塼Ǥϡι¤ֿεʤ襤פȷƤ졢Ἣ餳äƤ롣

ִñ˸ޤȡҥȤiPS˦ϼʬΤۤ˺äƤ䡢ȥꥫΥ٥㡼ȤĥޤƱҤõƤ򸫤顢礬˽дꤷƤƤȤۤȤɰʤ⤦褹ĤǤƤ櫓Ǥ͡סʡؽī١2014ǯ117

ޤȥʤȤ᤿ʳإ㡼ʥꥹȤ⼡Τ褦ʸҤ٤

2015-12-16_181224

־ػʸΰѤޤޤ뺣ʸǤSTAP˦¸ߤȤϸޤ󡣤ES˦iPS˦ǤϤʤ˦ǽ˦ˤ˶ᤤ¸ߡiMuSCs˦٤ĤäȤϳΤǤ

ϡSTAP˦ˤĤơ漼¢ˤˤäES˦κäȷŤƤޤ󼨤¸ǡǽ˦ޤƤǽϤޤȤȤǤ礦ϡ餷鲺䤫ʷ̤ǤϤʤϤǤסʲʳإ㡼ʥꥹȡ

2015-12-16_181212

ʤߤˡ̵ռΥåʹȤ֥Сԡʵպˡ׵ѤǾθդʬϤȡϲ񸫤ǡ֤ȤӥͥαĶŪʡġסֻ䤬סֺ줫Ǥ⤽ˤĤơȯɽƥˡפʤɤȯƤȤȽƤ롣ߡܤǤSTAP˦ᥦ路Τ̾Τ褦ʰƤ롣ʣʼФ뤳Ȥʤǽ˦߽ФȤSTAP˦ƱͤΥ󥻥ץȤǤβʳؼԤʶ򷫤깭Ƥꡢ⤽αˤäȤϴְ㤤ʤ褦Խ

͡Ҥؤƻɵڤ֤ͭβסScientific ReportsסܷкѿʹסХӥͥסۤ

ȸ TOCANA




ֻϺ׻ϡSTAP˦ǤΤϡϸ-椷ƤĥȤGHQ¸³ǧ줿롼פǡޤԻΥǡꥫ¦Ϥ뤳ȤȻȤ줿Ȥ⤬ꡢꥫȥ֥֤ȿǤǡǯ奢ꥫ-STAP˦˶ᤤΤȯɽȤ˲Ȼפȸä

ˡֿĿϺ׻᤬Υץˤʤ˺Ѥޤޤͥ㡼-ǺܤΤꤲͥ㡼STAP˦Ǥٺ򤬤äǥꥫΥΡϼ겼ʤäΤȸޤֵܲˮɧ׻Ҥ٤ΤǤSTAP˦ѤꤷߤФ褤ΤǤ-Ȥεˡܤϥꥫο̱Ϥդ館ʤȸä

ޤ֥٥󥸥ߥ󡦥եեɡ׻᤬ʹ顢祦祦Хΰ-ˤ̿3ܤ˿ӡʹ֤ƱҤäƤ뤬ʹ֤ˤϻѤʤǸƤȡѱѤѤΤ٤ȸȬѵ׻ϡҤõäƤ20ǯˤϸǡ¿20ǯǤϥȤǤ¤줿ǯǤ٤ʤȤ׻ΩĤΤ⤷ʤȸä




񸫤STAP˦õ¤򱣤٤äƤϢΰϤǤʲ񸫤򤷤Τ餫





ڣӣԣк˦ϣ¤һƵǷȯ

ƵǾһ򷺻ȯ

2015ǯ124 70ʬ
 
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ӣԣк˦ȯȤʸǸǧꤵ졢ظʹ࿦һʣˤƵǷȯ뤳ȤˤʤäȯΤϺǯޤˤϣ¤ҵ׻ʣˤǾϡ᤯ФĨʬǤȤȤʤɤȤ쥿žȤؤβǽꤶƤ롣ٻȯܺȤФɤǤϤʤʤ롣

ȯμ̿ե饤ǡμϡǯޤ͸ŵѴ׸ץΥơޥ꡼̳Ƥʪ־᤬ţӺ˦㻳ɧθ漼ڵ򤽤פȤơʼ˸٤˶᤯ƵǷȯͤ

ӣԣк˦ᤰäƤϺǯƸ¸ʤäȤȯɽƤ롣ĴѰϡӣԣк˦ΡΡɤˤĤơ̤ǽ˦ǤţӺ˦Ƥǽ⤤פȤθ򼨤ʸǿˣĤ¤ʤͤĤˤǧꤷ

ţӺ˦ɤΤ褦ʷаޤǺ줿Τä᤬ȤƹȯȤʤȰ

Ʊؤμô㡼ʥꥹȤůʣˤϡϣˤ⡢ʼ˸٤˹ȯФ롣ôԤ뤳ȤǤ碌Ѥߡפä

ϾϤʤܤβʳؤؤο꤬ϤפȤƹȯաοʹ֤ǤСǯʳǾİƤ롣ϻʰϢˤ˶ᤤͤˤ񤤤ˤʤäơڵ򽸤᤿פĻ³롣

ȯźդڵϡ漼ˤä֣ĤȢפäƤ֥塼֡פμ̿ܤȢΥ塼֤ˤϣţӺ˦äƤܤȢΥ塼֤ˤϡ֣ӣԣд˦פȽ񤫤ƤΤäȤȤϣţӺ˦ʤ̤κ˦äƤȤ

᤬̾󤲤㻳ϣӣԣк˦ʸζԤΣ͡߶̳뻳˶̳˸漼򹽤ϸȤƺҤƤμ㻳ܤƤţӺ˦ȾüɤƱȤߤΤǸĤäȤϺǯ󤸤Ƥ

Ϥηܺ٤Ĵپ夲᤬ţӺ˦ӣԣк˦ȵäƤȤã

Ļϡַٻˤϼ̿塼֤ΥꥹȤФ뤽ǤʪϤޤˤǤ礦ȢνͭˤΤǡﳲϤФ뤳Ȥ˾ʤפȤߤƤ뤬ιȯǡַٻưС˶ܺäȢİ褵פȻ֤ưǽŦ롣

ϢϤޤƳĴƤĤܺؤǽФƤ櫓

ϣţӺ˦κӤꡣȯФ̾»ʾ٤ʤɤȿ˽Фǽ⤢롣ϡʤƤΩġ٤ȤääƤ롣͡ʻڽ۸Ρˤ˼򿽤Ƥ館ʤäסĻ

ĴѤο¤ǧФϣδ¤ޤǤΩƤ򤷤ʤäᡢդǧꤵ줿Τȹ碌ƷףθꤷƤ롣ϾνʬĨѰ˺ƳΤΡǤ࿦Ƥ뤿ᡢ¼Ūˤ̵̣

Τᡢ̲ǤϾžȤᤰäƥƥӶɤǽץʤɤˤå郎ϤޤȤ⤤ƤȯȤʤж̤ϤޤääƤ

ȸ 쥹Web




ڴϢ
̵Ȥʤäһ˸3500ִβǽ²ˤŤ

۸ΤĹë͵־Ҥϡ3˽λĴ̼ǤϡǤηʤͤ

̵Ȥʤäһ˸3500ִβǽ²ˤŤ

STAP˦¸ߤһμ²ȤξƤλѤä

2014.12.26 07:00
 
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ʪؤˤʤ̿סֿʹ֤ϿΰäרβʳؼԤäƶòŤȯŸԤ˾´Ԥ˾ͿϡΤʤäΤ

2014ǯ1219ظϿǽ˦ȤSTAP˦פˤĤơڼ¸η̡¸ߤǧǤʤäȯɽ¸ǻߤ˦1800ĤˤΤܤäSTAP˦ͭޥϰɤʤä

ξҤ31͡ˤɮƬԤˤʸ1˱ѥͥ㡼˷ǺܤưʹߡȯФ4β񸫤ǡSTAP˦ϤޡפΤΡ򴬤ϢưϡǽޤȤˤʤ롣

žȤȤ1219˥磻ɥ硼ľϡȱӤХåꡢ硼ȥåȤˤо졣ǤƱ21դ࿦ѤߤȽʬɤϤޤä櫓ǤϤʤ

STAP˦䤷ѤϡκƸ¸ޤ3500ߤˤΤܤ뤬Τ⤬˸ƤΤ

ǶưƤȿǤϢθѤŪʤΤǡľĿͤ˲ƤΤȤ顢᤿ǤäƤ⡢ִܿͤ᤬ԤǽϤޤ͡סذʳظξ徻

̵ȤʤäʧˤϤޤˤۤǡ˰ǫˬΤϡޤΤȤˤʤꤽˡϢưϡβ²ˤŤƤȤƤ

ؤǿؤζ̳ƤϡȾǯ֡ؤ٤ळȤּȤϵٹ֤ФäסƱسˤȤոˤ²Ȥ⡢ǶŤޤ꤫äޤޤǤ롣

ȯФƤϡޤäξƤλѤ򸫤ʤʤޤĤⱫͤĤ᤭äޤޤǡġ㤵ʤ㤤Фʤ󤫤򤷤Ƥ⤢ޤǶϤޤäޤסʶٽ̱

֥2015ǯ1815

ȸ NEWSݥȥ֥



ڴϢ
۸ΤĹë͵־Ҥϡ3˽λĴ̼ǤϡǤηʤͤ

®۾ξʡκ˧󥿡Ĺ˴βǽ

۸ΤĹë͵־Ҥϡ3˽λĴ̼ǤϡǤηʤͤ

һᡡĴǺǤηʤפ۸

2014.12.17 07:00

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ظξһؤνʬϡǯ3ˤФȸƤ롣ϡη򹹿ʤפȤȽǤƱڤ뤳ȤǽǤ뤳Ȥ̣롣ˤĨۡפǤϤʤʤ뤿ᡢϫƯ˴ؤʾٺ򤱤롣Ǥ¦ʤΤλƤǤ롣

3˹Ԥʤä񸫤ˤС˥åȥ꡼äˤϡ1ǯ֤Ǹ1000ߤȡθѤʤɤ˻Ȥͷ1000ߤη2000ߤʬƤǯ6ߤκ渦漼θѤƤǽŦƤ롣θ¿ǶǤ롣۸ΤĹë͵᤬

3˽λĴ̼ǤϡǤηʤͤޤ⤷ʤSTAP˦򤢤뤫Τ褦˸Ƹ٤äǤΩϴñǤϤʤ·Ȥʤ10ǯʲĨˤʤ롣ޤ̱Ǥ»᤬ԤʤǽϤޤ

ϢǤϡΥХʥ󥹤꤬äȤϴְ㤤ʤΤϤȤΩƤʤΤΩˡͤȤƷǤ򰷤ʾ塢ˤ뤳Ȥϵʤ

ϵǤȤʤäȯʳ縦楻󥿡פΤ1121դǡ¿˦ƥ楻󥿡פ˺Ԥϥ˥åȥ꡼ο򤫤졢̸¸ԤդȤʤäΤȤϡͤˤ뼫ޥ󥷥餷Ƥ褦նν̱

ֺǶϤ򼰤Τ褦ʹĤƤޤ񸫤λꤵ餻ƤơجäƤʷϵǤޤ㤵ȻפȱˬͤƤޤ쥯ޤ⤢ä

²ˤȤäƤ⸷줷ǯ

ݥ2014ǯ1226

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